Universität zu Köln

Neuschmelting, Volker, Burton, Neal C., Lockau, Hannah, Urich, Alexander, Harmsen, Stefan ORCID: 0000-0001-5812-7299, Ntziachristos, Vasilis and Kircher, Moritz F. (2016). Performance of a Multispectral Optoacoustic Tomography (MSOT) System equipped with 2D vs. 3D Handheld Probes for Potential Clinical Translation. Photoacoustics, 4 (1). S. 1 - 11. JENA: ELSEVIER GMBH, URBAN & FISCHER VERLAG. ISSN 2213-5979

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Abstract

A handheld approach to optoacoustic imaging is essential for the clinical translation. The first 2- and 3-dimensional handheld multispectral optoacoustic tomography (MSOT) probes featuring real-time unmixing have recently been developed. Imaging performance of both probes was determined in vitro and in a brain melanoma metastasis mouse model in vivo. T1-weighted MR images were acquired for anatomical reference. The limit of detection of melanoma cells in vitro was significantly lower using the 2D than the 3D probe. The signal decrease was more profound in relation to depth with the 3D versus the 2D probe. Both approaches were capable of imaging the melanoma tumors qualitatively at all time points. Quantitatively, the 2D approach enabled closer anatomical resemblance of the tumor compared to the 3D probe, particularly at depths beyond 3 mm. The 3D probe was shown to be superior for rapid 3D imaging and, thus, holds promise for more superficial target structures. (C) 2015 The Authors. Published by Elsevier GmbH.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Neuschmelting, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Burton, Neal C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lockau, Hannah UNSPECIFIED UNSPECIFIED UNSPECIFIED Urich, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Harmsen, Stefan UNSPECIFIED orcid.org/0000-0001-5812-7299 UNSPECIFIED Ntziachristos, Vasilis UNSPECIFIED UNSPECIFIED UNSPECIFIED Kircher, Moritz F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-284029
DOI:	10.1016/j.pacs.2015.12.001
Journal or Publication Title:	Photoacoustics
Volume:	4
Number:	1
Page Range:	S. 1 - 11
Date:	2016
Publisher:	ELSEVIER GMBH, URBAN & FISCHER VERLAG
Place of Publication:	JENA
ISSN:	2213-5979
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IN-VIVO; BRAIN; MICROSCOPY Multiple languages Acoustics; Engineering, Biomedical; Instruments & Instrumentation; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28402