Universität zu Köln

Derst, Christian, Dircksen, Heinrich ORCID: 0000-0001-7815-4868, Meusemann, Karen, Zhou, Xin ORCID: 0000-0002-1407-7952, Liu, Shanlin and Predel, Reinhard (2016). Evolution of neuropeptides in non-pterygote hexapods. BMC Evol. Biol., 16. LONDON: BMC. ISSN 1471-2148

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Abstract

Background: Neuropeptides are key players in information transfer and act as important regulators of development, growth, metabolism, and reproduction within multi-cellular animal organisms (Metazoa). These short protein-like substances show a high degree of structural variability and are recognized as the most diverse group of messenger molecules. We used transcriptome sequences from the 1KITE (1K Insect Transcriptome Evolution) project to search for neuropeptide coding sequences in 24 species from the non-pterygote hexapod lineages Protura (coneheads), Collembola (springtails), Diplura (two-pronged bristletails), Archaeognatha (jumping bristletails), and Zygentoma (silverfish and firebrats), which are often referred to as basal hexapods. Phylogenetically, Protura, Collembola, Diplura, and Archaeognatha are currently placed between Remipedia and Pterygota (winged insects); Zygentoma is the sistergroup of Pterygota. The Remipedia are assumed to be among the closest relatives of all hexapods and belong to the crustaceans. Results: We identified neuropeptide precursor sequences within whole-body transcriptome data from these five hexapod groups and complemented this dataset with homologous sequences from three crustaceans (including Daphnia pulex), three myriapods, and the fruit fly Drosophila melanogaster. Our results indicate that the reported loss of several neuropeptide genes in a number of winged insects, particularly holometabolous insects, is a trend that has occurred within Pterygota. The neuropeptide precursor sequences of the non-pterygote hexapods show numerous amino acid substitutions, gene duplications, variants following alternative splicing, and numbers of paracopies. Nevertheless, most of these features fall within the range of variation known from pterygote insects. However, the capa/pyrokinin genes of non-pterygote hexapods provide an interesting example of rapid evolution, including duplication of a neuropeptide gene encoding different ligands. Conclusions: Our findings delineate a basic pattern of neuropeptide sequences that existed before lineage-specific developments occurred during the evolution of pterygote insects.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Derst, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Dircksen, Heinrich UNSPECIFIED orcid.org/0000-0001-7815-4868 UNSPECIFIED Meusemann, Karen UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhou, Xin UNSPECIFIED orcid.org/0000-0002-1407-7952 UNSPECIFIED Liu, Shanlin UNSPECIFIED UNSPECIFIED UNSPECIFIED Predel, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-284206
DOI:	10.1186/s12862-016-0621-4
Journal or Publication Title:	BMC Evol. Biol.
Volume:	16
Date:	2016
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1471-2148
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ADULT DROSOPHILA-MELANOGASTER; CENTRAL-NERVOUS-SYSTEM; PROTEIN HORMONES; INSECT; PEPTIDOMICS; PEPTIDES; EXPRESSION; GENOMICS; TRANSCRIPTOMICS; RECEPTORS Multiple languages Evolutionary Biology; Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28420