Universität zu Köln

Bonfig, Walter, Roehl, Friedrich-Wilhelm, Riedl, Stefan, Doerr, Helmut Guenther, Bettendorf, Markus, Braemswig, Juergen, Schoenau, Eckhard, Riepe, Felix, Hauffa, Berthold, Holl, Reinhard W. and Mohnike, Klaus (2016). Blood Pressure in a Large Cohort of Children and Adolescents With Classic Adrenal Hyperplasia (CAH) Due to 21-Hydroxylase Deficiency. Am. J. Hypertens., 29 (2). S. 266 - 273. OXFORD: OXFORD UNIV PRESS. ISSN 1941-7225

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Abstract

BACKGROUND Data on blood pressure (BP) in children and adolescents with classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency are conflicting in the literature. PATIENTS AND METHODS BP data of n = 716 children and adolescents (aged 3-18 years) from a national CAH database were analyzed. BP data were adjusted for height and compared to contemporary national reference data. A systolic and diastolic BP above the 95th centile was defined as hypertensive. RESULTS Overall prevalence of hypertension was 12.5%. Prevalence of hypertension was higher in younger children than in adolescents (18.5% vs. 4.9%). Until 8 years of age, fludrocortisone dose/m(2)/day correlated significantly with BP in regression analysis (P < 0.0001). BP correlated significantly with body mass index standard deviation score (BMI-SDS) (P < 0.0001), but not with hydrocortisone dose. In patients with salt-wasting CAH, BMI-SDS and BP were significantly higher compared to patients with simple virilising CAH, P < 0.01. CONCLUSION Especially young CAH children seem to be at risk for-most likely transient-hypertension, since the prevalence of hypertension decreases with age. In children up to 8 years of age, the used fludrocortisone dose is a significant risk factor for hypertension. Therefore we recommend accurate measurement of BP and careful fludrocortisone dosing in children with CAH.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bonfig, Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED Roehl, Friedrich-Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedl, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Doerr, Helmut Guenther UNSPECIFIED UNSPECIFIED UNSPECIFIED Bettendorf, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Braemswig, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenau, Eckhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Riepe, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Hauffa, Berthold UNSPECIFIED UNSPECIFIED UNSPECIFIED Holl, Reinhard W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mohnike, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-285329
DOI:	10.1093/ajh/hpv087
Journal or Publication Title:	Am. J. Hypertens.
Volume:	29
Number:	2
Page Range:	S. 266 - 273
Date:	2016
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1941-7225
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Peripheral Vascular Disease Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28532