Universität zu Köln

Akkina, Ramesh, Allam, Atef, Balazs, Alejandro B., Blankson, Joel N., Burnett, John C., Casares, Sofia, Garcia, J. Victor, Hasenkrug, Kim J., Kashanchi, Fatah, Kitchen, Scott G., Klein, Florian, Kumar, Priti, Luster, Andrew D., Poluektova, Larisa Y., Rao, Mangala, Sanders-Beer, Brigitte E., Shultz, Leonard D. and Zack, Jerome A. (2016). Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID Meet the Experts 2015 Workshop Summary. Aids Res. Hum. Retrovir., 32 (2). S. 109 - 120. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 1931-8405

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Abstract

The number of humanized mouse models for the human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) and other infectious diseases has expanded rapidly over the past 8 years. Highly immunodeficient mouse strains, such as NOD/SCID/gamma chain(null) (NSG, NOG), support better human hematopoietic cell engraftment. Another improvement is the derivation of highly immunodeficient mice, transgenic with human leukocyte antigens (HLAs) and cytokines that supported development of HLA-restricted human T cells and heightened human myeloid cell engraftment. Humanized mice are also used to study the HIV reservoir using new imaging techniques. Despite these advances, there are still limitations in HIV immune responses and deficits in lymphoid structures in these models in addition to xenogeneic graft-versus-host responses. To understand and disseminate the improvements and limitations of humanized mouse models to the scientific community, the NIH sponsored and convened a meeting on April 15, 2015 to discuss the state of knowledge concerning these questions and best practices for selecting a humanized mouse model for a particular scientific investigation. This report summarizes the findings of the NIH meeting.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Akkina, Ramesh UNSPECIFIED UNSPECIFIED UNSPECIFIED Allam, Atef UNSPECIFIED UNSPECIFIED UNSPECIFIED Balazs, Alejandro B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Blankson, Joel N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Burnett, John C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Casares, Sofia UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia, J. Victor UNSPECIFIED UNSPECIFIED UNSPECIFIED Hasenkrug, Kim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kashanchi, Fatah UNSPECIFIED UNSPECIFIED UNSPECIFIED Kitchen, Scott G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kumar, Priti UNSPECIFIED UNSPECIFIED UNSPECIFIED Luster, Andrew D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Poluektova, Larisa Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rao, Mangala UNSPECIFIED UNSPECIFIED UNSPECIFIED Sanders-Beer, Brigitte E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shultz, Leonard D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zack, Jerome A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-285557
DOI:	10.1089/aid.2015.0258
Journal or Publication Title:	Aids Res. Hum. Retrovir.
Volume:	32
Number:	2
Page Range:	S. 109 - 120
Date:	2016
Publisher:	MARY ANN LIEBERT, INC
Place of Publication:	NEW ROCHELLE
ISSN:	1931-8405
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IMMUNODEFICIENCY-VIRUS ENCEPHALITIS; BROADLY NEUTRALIZING ANTIBODIES; SCID-HU MOUSE; T-CELLS; IN-VIVO; IMMUNE-RESPONSES; MURINE MODEL; VIRAL LOADS; DRAG MICE; GENERATION Multiple languages Immunology; Infectious Diseases; Virology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28555