Universität zu Köln

Rey, J. W., Deris, N., Marquardt, J. U., Thomaidis, T., Moehler, M., Kittner, J. M., Nguyen-Tat, M., Duemcke, S., Tresch, A., Biesterfeld, S., Goetz, M., Mudter, J., Neurath, M. F., Galle, P. R., Kiesslich, R. and Hoffman, A. (2016). High-definition endoscopy with iScan and Lugol's solution for the detection of inflammation in patients with nonerosive reflux disease: histologic evaluation in comparison with a control group. Dis. Esophagus, 29 (2). S. 185 - 192. CARY: OXFORD UNIV PRESS INC. ISSN 1442-2050

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Abstract

Nonerosive reflux disease (NERD) is commonly diagnosed in patients with symptoms of reflux. The aim of the present study was to determine whether high-definition endoscopy (HD) plus equipped with the iScan function or chromoendoscopy with Lugol's solution might permit the differentiation of NERD patients from those without reflux symptoms, proven by targeted biopsies of endoscopic lesions. A total of 100 patients without regular intake of proton pump inhibitors and with a normal conventional upper endoscopy were prospectively divided into NERD patients and controls. A second upper endoscopy was performed using HD+ with additional iScan function and then Lugol's solution was applied. Biopsy specimens were taken from the gastroesophageal junction in all patients. A total of 65 patients with reflux symptoms and 27 controls were included. HD+ endoscopy with iScan revealed subtle mucosal breaks in 52 patients; the subsequent biopsies confirmed esophagitis in all cases. After Lugol's solution, 58 patients showed mucosal breaks. Sensitivity for the iScan procedure was 82.5%, whereas that for Lugol's solution was 92.06%. Excellent positive predictive values of 100% and 98.3%, respectively, were noted. The present study suggests that the majority of patients with NERD and typical symptoms of reflux disease can be identified by iScan or Lugol's chromoendoscopy as minimal erosive reFLux disease (ERD) patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rey, J. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Deris, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marquardt, J. U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomaidis, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moehler, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kittner, J. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nguyen-Tat, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Duemcke, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tresch, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Biesterfeld, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goetz, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mudter, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Neurath, M. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Galle, P. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kiesslich, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffman, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-286199
DOI:	10.1111/dote.12308
Journal or Publication Title:	Dis. Esophagus
Volume:	29
Number:	2
Page Range:	S. 185 - 192
Date:	2016
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1442-2050
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COMPUTED VIRTUAL CHROMOENDOSCOPY; MINIMAL CHANGE ESOPHAGITIS; BARRETTS-ESOPHAGUS; DIAGNOSIS; COLONOSCOPY; COMMUNITY Multiple languages Gastroenterology & Hepatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28619