Universität zu Köln

Kuhnert, Georg, Boellaard, Ronald ORCID: 0000-0002-0313-5686, Sterzer, Sergej, Kahraman, Deniz, Scheffler, Matthias ORCID: 0000-0002-9031-1368, Wolf, Juergen, Dietlein, Markus, Drzezga, Alexander and Kobe, Carsten (2016). Impact of PET/CT image reconstruction methods and liver uptake normalization strategies on quantitative image analysis. Eur. J. Nucl. Med. Mol. Imaging, 43 (2). S. 249 - 259. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

Background In oncological imaging using PET/CT, the standardized uptake value has become the most common parameter used to measure tracer accumulation. The aim of this analysis was to evaluate ultra high definition (UHD) and ordered subset expectation maximization (OSEM) PET/CT reconstructions for their potential impact on quantification. Patients and methods We analyzed 40 PET/CT scans of lung cancer patients who had undergone PET/CT. Standardized uptake values corrected for body weight (SUV) and lean body mass (SUL) were determined in the single hottest lesion in the lung and normalized to the liver for UHD and OSEM reconstruction. Quantitative uptake values and their normalized ratios for the two reconstruction settings were compared using the Wilcoxon test. The distribution of quantitative uptake values and their ratios in relation to the reconstruction method used were demonstrated in the form of frequency distribution curves, box-plots and scatter plots. The agreement between OSEM and UHD reconstructions was assessed through Bland-Altman analysis. Results A significant difference was observed after OSEM and UHD reconstruction for SUV and SUL data tested (p < 0.0005 in all cases). The mean values of the ratios after OSEM and UHD reconstruction showed equally significant differences (p < 0.0005 in all cases). Bland-Altman analysis showed that the SUV and SUL and their normalized values were, on average, up to 60 % higher after UHD reconstruction as compared to OSEM reconstruction. Conclusion OSEM and HD reconstruction brought a significant difference for SUV and SUL, which remained constantly high after normalization to the liver, indicating that standardization of reconstruction and the use of comparable SUV measurements are crucial when using PET/CT.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kuhnert, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Boellaard, Ronald UNSPECIFIED orcid.org/0000-0002-0313-5686 UNSPECIFIED Sterzer, Sergej UNSPECIFIED UNSPECIFIED UNSPECIFIED Kahraman, Deniz UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheffler, Matthias UNSPECIFIED orcid.org/0000-0002-9031-1368 UNSPECIFIED Wolf, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Kobe, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-286229
DOI:	10.1007/s00259-015-3165-8
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	43
Number:	2
Page Range:	S. 249 - 259
Date:	2016
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STANDARDIZED UPTAKE VALUE; POINT-SPREAD FUNCTION; CELL LUNG-CANCER; SILLY USELESS VALUE; TIME-OF-FLIGHT; FDG-PET; MULTICENTER TRIALS; HODGKIN LYMPHOMA; SUV MEASUREMENTS; F-18-FDG PET/CT Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28622