Universität zu Köln

Khalfaoui, Soumaya, Eichhorn, Vivien, Karagiannidis, Christian, Bayh, Inga, Brockmann, Michael, Pieper, Monika, Windisch, Wolfram, Schildgen, Oliver ORCID: 0000-0003-4297-9627 and Schildgen, Verena (2016). Lung Infection by Human Bocavirus Induces the Release of Profibrotic Mediator Cytokines In Vivo and In Vitro. PLoS One, 11 (1). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Human Bocavirus subtype 1 (HBoV1) is associated with respiratory diseases and may contribute to chronic lung diseases by persisting in the infected host. Here the question was addressed if HBoV infections could contribute to fibrogenesis processes as suggested by previously published clinical observations. Cytokine profiles induced by HBoV infection in CuFi-8 air-liquid interphase cell cultures and in bronchoalveolar lavage fluid (BALF) of 20 HBoV-positive and 12 HBoV-negative patients were analysed by semi-quantitative Western spot blot analyses. Although lots of cytokines were regulated independently of HBoV status, several cytokines associated with lung fibrosis and tumour development, e.g., EGF, VEGF, TARC (CCL17), TNF-alpha, TNF-beta, TIMP-1, were clearly upregulated in the HBoV-positive cohort. These findings suggest that the development of lung fibrosis might be triggered by HBoV induced cytokine expression.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Khalfaoui, Soumaya UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichhorn, Vivien UNSPECIFIED UNSPECIFIED UNSPECIFIED Karagiannidis, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Bayh, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Brockmann, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Pieper, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Windisch, Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildgen, Oliver UNSPECIFIED orcid.org/0000-0003-4297-9627 UNSPECIFIED Schildgen, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-286999
DOI:	10.1371/journal.pone.0147010
Journal or Publication Title:	PLoS One
Volume:	11
Number:	1
Date:	2016
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN PARVOVIRUS B19; TNF-ALPHA; PULMONARY-FIBROSIS; LIVER FIBROSIS; POOR-PROGNOSIS; COMMON COLD; IFN-GAMMA; GM-CSF; CANCER; DNA Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28699