Universität zu Köln

Rabe, Patrick ORCID: 0000-0002-3448-9559, Janusko, Aron, Goldfuss, Bernd ORCID: 0000-0002-1814-8818 and Dickschat, Jeroen S. (2016). Experimental and Theoretical Studies on Corvol Ether Biosynthesis. ChemBioChem, 17 (2). S. 146 - 150. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1439-7633

Full text not available from this repository.

Abstract

The biosynthesis of corvol ethers A and B, two sesquiterpenes from Kitasatospora setae, proceeds with involvement of either one 1,3-or two sequential 1,2-hydride shifts. Quantum chemical calculations revealed that the sequence of two 1,2-hydride shifts is energetically favoured. Labelling experiments were in agreement with this finding. In addition, the stereochemical course of a reprotonation step was investigated by incubation of C-13-labelled isotopomers of farnesyl diphosphate in water and in deuterium oxide.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rabe, Patrick UNSPECIFIED orcid.org/0000-0002-3448-9559 UNSPECIFIED Janusko, Aron UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldfuss, Bernd UNSPECIFIED orcid.org/0000-0002-1814-8818 UNSPECIFIED Dickschat, Jeroen S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-287185
DOI:	10.1002/cbic.201500543
Journal or Publication Title:	ChemBioChem
Volume:	17
Number:	2
Page Range:	S. 146 - 150
Date:	2016
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1439-7633
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Organic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PENTALENENE SYNTHASE; STREPTOMYCES-COELICOLOR; SESQUITERPENE SYNTHASE; CRYSTAL-STRUCTURE; CYCLIZATION; MECHANISM; DENSITY; REARRANGEMENT; STEREOCHEMISTRY; TEMPLATES Multiple languages Biochemistry & Molecular Biology; Chemistry, Medicinal Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28718