Universität zu Köln

Emilova, R., Dimitrova, D. Z., Mladenov, M., Hadzi-Petrushev, N., Daneva, T., Padeshki, P., Schubert, R., Chichova, M., Lubomirov, L., Simeonovska-Nikolova, D. and Gagov, H. (2016). Diabetes Converts Arterial Regulation by Perivascular Adipose Tissue From Relaxation Into H2O2-Mediated Contraction. Physiol. Res., 65 (5). S. 799 - 808. PRAGUE 4: ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY. ISSN 1802-9973

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Abstract

This study aims to reveal the reason for the increased force of 5-hydroxytryptamine-induced contraction of endotheliumdenuded skeletal muscle arteries of diabetic rats in the presence of perivascular adipose tissue (PVAT). Our data on rat gracilis arteries show that i) PVAT of skeletal muscle arteries of healthy and diabetic rats releases hydrogen peroxide (H2O2), ii) higher concentrations of 5-hydroxytryptamine increase the production of H2O2 in PVAT; iii) an enhanced PVAT production of H2O2 is the main, if not the only, reason for the sensitization of arterial contraction to 5-hydroxytriptamine-induced contraction in diabetes and iv) endothelium antagonizes the effect of PVATderived H2O2.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Emilova, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dimitrova, D. Z. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mladenov, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hadzi-Petrushev, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Daneva, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Padeshki, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schubert, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chichova, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lubomirov, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Simeonovska-Nikolova, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gagov, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-288595
DOI:	10.33549/physiolres.933037
Journal or Publication Title:	Physiol. Res.
Volume:	65
Number:	5
Page Range:	S. 799 - 808
Date:	2016
Publisher:	ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
Place of Publication:	PRAGUE 4
ISSN:	1802-9973
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HYDROGEN-PEROXIDE; OXIDANT STRESS; MODULATION; AORTA; RATS; FAT Multiple languages Physiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28859