Universität zu Köln

Meyer, Hajo, Brenner, Markus, Hoefert, Simon-P., Knedel, Tim-O., Kunz, Peter C., Schmidt, Annette M., Hamacher, Alexandra, Kassack, Matthias U. and Janiak, Christoph ORCID: 0000-0002-6288-9605 (2016). Synthesis of oxime-based CO-releasing molecules, CORMs and their immobilization on maghemite nanoparticles for magnetic-field induced CO release. Dalton Trans., 45 (18). S. 7605 - 7616. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 1477-9234

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Abstract

Oxime-based CO-releasing molecules (oximeCORMs) were immobilized with a catechol-modified backbone on maghemite iron oxide nanoparticles (IONPs) to give oximeCORM@IONP. The CO release from the free and immobilized oximeCORMs was measured using the standard myoglobin assay. The oxime-CORM-nanoparticles were coated with dextran for improved water solubility and confined into an alginate shell for protection and separation from the surrounding myoglobin assay to allow for CO release studies by UV/Vis absorption without interference from highly-absorptive oximeCORM@IONP. Half-lifes of the oxime-based polymer-confined alginate@dextran@oximeCORM@IONPs were estimated at 20 degrees C to 814 +/- 23 min, at 37 degrees C to 346 +/- 83 min and at 50 degrees C to 73 +/- 1 min. The alginate@dextran@oximeCORM@IONP composite showed a further decrease of the half-life of CO release to 153 +/- 27 min at 37 degrees C through local magnetic heating of the susceptible iron oxide nanoparticles with application of an external alternating magnetic field (31.7 kA m(-1), 247 kHz, 39.9 mTesla). The activation energy for the CO release from molecular dicarbonylchlorido(imidazole-2-carbaldehydeoxime)(alkoxycarbonyl)ruthenium(II) complexes is determined to be similar to 100 kJ mol(-1) for five different imidazole-oxime derivatives.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Meyer, Hajo UNSPECIFIED UNSPECIFIED UNSPECIFIED Brenner, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoefert, Simon-P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knedel, Tim-O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kunz, Peter C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Annette M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamacher, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassack, Matthias U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Janiak, Christoph UNSPECIFIED orcid.org/0000-0002-6288-9605 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-290044
DOI:	10.1039/c5dt04888e
Journal or Publication Title:	Dalton Trans.
Volume:	45
Number:	18
Page Range:	S. 7605 - 7616
Date:	2016
Publisher:	ROYAL SOC CHEMISTRY
Place of Publication:	CAMBRIDGE
ISSN:	1477-9234
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IRON-OXIDE NANOPARTICLES; CARBON-MONOXIDE; METAL-CARBONYLS; MACROMOLECULAR THERAPEUTICS; HEME OXYGENASE; NITRIC-OXIDE; LIVING CELLS; COMPLEXES; PHARMACEUTICALS; CHEMISTRY Multiple languages Chemistry, Inorganic & Nuclear Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29004