Michels, Sebastian, Scheel, Andreas Hans, Scheffler, Matthias ORCID: 0000-0002-9031-1368, Schultheis, Anne Maria, Gautschi, Oliver, Aebersold, Franziska, Diebold, Joachim, Pall, Georg, Rothschild, Sacha ORCID: 0000-0003-1304-9340, Bubendorf, Lukas, Hartmann, Wolfgang ORCID: 0000-0002-7609-5021, Heukamp, Lukas ORCID: 0000-0002-3388-3482, Schildhaus, Hans-Ulrich, Fassunke, Jana, Ihle, Michaela Angelika, Kuenstlinger, Helen, Heydt, Carina, Fischer, Rieke, Nogova, Lucia, Mattonet, Christian, Hein, Rebecca, Adams, Anne ORCID: 0000-0003-3286-1131, Gerigk, Ulrich, Schulte, Wolfgang, Lueders, Heike, Grohe, Christian, Graeven, Ullrich, Mueller-Naendrup, Clemens, Draube, Andreas, Kambartel, Karl-Otto, Krueger, Stefan, Schulze-Olden, Susanne, Serke, Monika, Engel-Riedel, Walburga, Kaminsky, Britta, Randerath, Winfried, Merkelbach-Bruse, Sabine, Buettner, Reinhard and Wolf, Juergen (2016). Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients. J. Thorac. Oncol., 11 (1). S. 122 - 127. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1556-1380

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Abstract

Introduction: Rearrangements of RET are rare oncogenic events in patients with non-small cell lung cancer (NSCLC). While the characterization of Asian patients suggests a predominance of nonsmokers of young age in this genetically defined lung cancer subgroup, little is known about the characteristics of non-Asian patients. We present the results of an analysis of a European cohort of patients with RET rearranged NSCLC. Methods: Nine hundred ninety-seven patients with KRAS/EGFR/ALK wildtype lung adenocarcinomas were analyzed using fluorescence in situ hybridization for RET fusions. Tumor specimens were molecularly profiled and clinicopathological characteristics of the patients were collected. Results: Rearrangements of RET were identified in 22 patients, with a prevalence of 2.2% in the KRAS/EGFR/ALK wildtype subgroup. Co-occurring genetic aberrations were detected in 10 patients, and the majority had mutations in TP53. The median age at diagnosis was 62 years (range, 39-80 years; mean +/- SD, 61 +/- 11.7 years) with a higher proportion of men (59% versus 41%). There was only a slight predominance of nonsmokers (54.5%) compared to current or former smokers (45.5%). Conclusions: Patients with RET rearranged adenocarcinomas represent a rare and heterogeneous NSCLC sub-group. In some contrast to published data, we see a high prevalence of current and former smokers in our white RET cohort. The significance of co-occurring aberrations, so far, is unclear. (C) 2015 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Michels, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheel, Andreas HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheffler, MatthiasUNSPECIFIEDorcid.org/0000-0002-9031-1368UNSPECIFIED
Schultheis, Anne MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gautschi, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aebersold, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diebold, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pall, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rothschild, SachaUNSPECIFIEDorcid.org/0000-0003-1304-9340UNSPECIFIED
Bubendorf, LukasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartmann, WolfgangUNSPECIFIEDorcid.org/0000-0002-7609-5021UNSPECIFIED
Heukamp, LukasUNSPECIFIEDorcid.org/0000-0002-3388-3482UNSPECIFIED
Schildhaus, Hans-UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fassunke, JanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ihle, Michaela AngelikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuenstlinger, HelenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heydt, CarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, RiekeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nogova, LuciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mattonet, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hein, RebeccaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adams, AnneUNSPECIFIEDorcid.org/0000-0003-3286-1131UNSPECIFIED
Gerigk, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulte, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lueders, HeikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grohe, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graeven, UllrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller-Naendrup, ClemensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Draube, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambartel, Karl-OttoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krueger, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulze-Olden, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Serke, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engel-Riedel, WalburgaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaminsky, BrittaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Randerath, WinfriedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Merkelbach-Bruse, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buettner, ReinhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolf, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-290390
DOI: 10.1016/j.jtho.2015.09.016
Journal or Publication Title: J. Thorac. Oncol.
Volume: 11
Number: 1
Page Range: S. 122 - 127
Date: 2016
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1556-1380
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
FUSIONSMultiple languages
Oncology; Respiratory SystemMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/29039

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