Universität zu Köln

Schilbach, L., Hoffstaedter, F., Mueller, V., Cieslik, E. C., Goya-Maldonado, R., Trost, S., Sorg, C., Riedl, V., Jardri, R., Sommer, I., Kogler, L., Derntl, B., Gruber, O. and Eickhoff, S. B. (2016). Transdiagnostic commonalities and differences in resting state functional connectivity of the default mode network in schizophrenia and major depression. NeuroImage-Clin., 10. S. 326 - 336. OXFORD: ELSEVIER SCI LTD. ISSN 2213-1582

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Abstract

Schizophrenia and depression are prevalent psychiatric disorders, but their underlying neural bases remains poorly understood. Neuroimaging evidence has pointed towards the relevance of functional connectivity aberrations in defaultmode network (DMN) hubs, dorso-medial prefrontal cortex and precuneus, in both disorders, but commonalities and differences in resting state functional connectivity of those two regions across disorders has not been formally assessed. Here, we took a transdiagnostic approach to investigate resting state functional connectivity of those two regions in 75 patients with schizophrenia and 82 controls from 4 scanning sites and 102 patients with depression and 106 controls from 3 sites. Our results demonstrate common dysconnectivity patterns as indexed by a significant reduction of functional connectivity between precuneus and bilateral superior parietal lobe in schizophrenia and depression. Furthermore, our findings highlight diagnosis-specific connectivity reductions of the parietal operculum in schizophrenia relative to depression. In light of evidence that points towards the importance of the DMN for social cognitive abilities and well documented impairments of social interaction in both patient groups, it is conceivable that the observed transdiagnostic connectivity alterations may contribute to interpersonal difficulties, but this could not be assessed directly in our study as measures of social behavior were not available. Given the operculum's role in somatosensory integration, diagnosis-specific connectivity reductions may indicate a pathophysiological mechanism for basic self-disturbances that is characteristic of schizophrenia, but not depression. (C) 2015 The Authors. Published by Elsevier Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schilbach, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffstaedter, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cieslik, E. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goya-Maldonado, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Trost, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sorg, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedl, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jardri, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sommer, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kogler, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Derntl, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruber, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, S. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-290408
DOI:	10.1016/j.nicl.2015.11.021
Journal or Publication Title:	NeuroImage-Clin.
Volume:	10
Page Range:	S. 326 - 336
Date:	2016
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	2213-1582
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MEMORY RETRIEVAL; BRAIN ACTIVITY; HIGH-RISK; MECHANISMS; SYMPTOMS; CORTEX; PSYCHOSIS; DISORDER; MOTION; PSYCHOPATHOLOGY Multiple languages Neuroimaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29040