Universität zu Köln

Lundt, Andreas, Wormuth, Carola, Siwek, Magdalena Elisabeth, Mueller, Ralf, Ehninger, Dan, Henseler, Christina, Broich, Karl, Papazoglou, Anna and Weiergraeber, Marco (2016). EEG Radiotelemetry in Small Laboratory Rodents: A Powerful State-of-the Art Approach in Neuropsychiatric, Neurodegenerative, and Epilepsy Research. Neural. Plast., 2016. LONDON: HINDAWI LTD. ISSN 1687-5443

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Abstract

EEG radiotelemetry plays an important role in the neurological characterization of transgenic mouse models of neuropsychiatric and neurodegenerative diseases as well as epilepsies providing valuable insights into underlying pathophysiological mechanisms and thereby facilitating the development of new translational approaches. We elaborate on the major advantages of nonrestraining EEG radiotelemetry in contrast to restraining procedures such as tethered systems or jacket systems containing recorders. Whereas a main disadvantage of the latter is their unphysiological, restraining character, telemetric EEG recording overcomes these disadvantages. It allows precise and highly sensitive measurement under various physiological and pathophysiological conditions. Here we present a detailed description of a straightforward successful, quick, and efficient technique for intraperitoneal as well as subcutaneous pouch implantation of a standard radiofrequency transmitter in mice and rats. We further present computerized 3D-stereotaxic placement of both epidural and deep intracerebral electrodes. Preoperative preparation of mice and rats, suitable anaesthesia, and postoperative treatment and pain management are described in detail. A special focus is on fields of application, technical and experimental pitfalls, and technical connections of commercially available radiotelemetry systems with other electrophysiological setups.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lundt, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Wormuth, Carola UNSPECIFIED UNSPECIFIED UNSPECIFIED Siwek, Magdalena Elisabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Ehninger, Dan UNSPECIFIED UNSPECIFIED UNSPECIFIED Henseler, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Broich, Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Papazoglou, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiergraeber, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-291782
DOI:	10.1155/2016/8213878
Journal or Publication Title:	Neural. Plast.
Volume:	2016
Date:	2016
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	1687-5443
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TELEMETRY SYSTEM; HEART-RATE; ENVIRONMENTAL ENRICHMENT; RECORDING EEG; BEHAVIORAL PHENOTYPES; BODY-TEMPERATURE; INDUCED SEIZURES; MICE ANESTHESIA; BLOOD-PRESSURE; ANIMAL-MODELS Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29178