Universität zu Köln

Weiss, Peter H. ORCID: 0000-0002-5230-9080, Ubben, Simon D., Kaesberg, Stephanie, Kalbe, Elke, Kessler, Josef, Liebig, Thomas and Fink, Gereon R. ORCID: 0000-0002-8230-1856 (2016). Where language meets meaningful action: a combined behavior and lesion analysis of aphasia and apraxia. Brain Struct. Funct., 221 (1). S. 563 - 577. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1863-2661

Full text not available from this repository.

Abstract

It is debated how language and praxis are co-represented in the left hemisphere (LH). As voxel-based lesion-symptom mapping in LH stroke patients with aphasia and/or apraxia may contribute to this debate, we here investigated the relationship between language and praxis deficits at the behavioral and lesion levels in 50 sub-acute stroke patients. We hypothesized that language and (meaningful) action are linked via semantic processing in Broca's region. Behaviorally, half of the patients suffered from co-morbid aphasia and apraxia. While 24 % (n = 12) of all patients exhibited aphasia without apraxia, apraxia without aphasia was rare (n = 2, 4 %). Left inferior frontal, insular, inferior parietal, and superior temporal lesions were specifically associated with deficits in naming, reading, writing, or auditory comprehension. In contrast, lesions affecting the left inferior frontal gyrus, premotor cortex, and the central region as well as the inferior parietal lobe were associated with apraxic deficits (i.e., pantomime, imitation of meaningful and meaningless gestures). Thus, contrary to the predictions of the embodied cognition theory, lesions to sensorimotor and premotor areas were associated with the severity of praxis but not language deficits. Lesions of Brodmann area (BA) 44 led to combined apraxic and aphasic deficits. Data suggest that BA 44 acts as an interface between language and (meaningful) action thereby supporting parcellation schemes (based on connectivity and receptor mapping) which revealed a BA 44 sub-area involved in semantic processing.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weiss, Peter H. UNSPECIFIED orcid.org/0000-0002-5230-9080 UNSPECIFIED Ubben, Simon D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaesberg, Stephanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Kessler, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Liebig, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-292469
DOI:	10.1007/s00429-014-0925-3
Journal or Publication Title:	Brain Struct. Funct.
Volume:	221
Number:	1
Page Range:	S. 563 - 577
Date:	2016
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1863-2661
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MIRROR-NEURON SYSTEM; BROCAS AREA; TOOL USE; GESTURE DISCRIMINATION; ACTION RECOGNITION; IDEOMOTOR APRAXIA; BRAIN-REGIONS; ACUTE STROKE; IMITATION; MECHANISMS Multiple languages Anatomy & Morphology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29246