Universität zu Köln

Frank, Stefan, Aguirre, Aitor ORCID: 0000-0002-1383-2792, Hescheler, Juergen and Kurian, Leo ORCID: 0000-0001-7466-5169 (2016). A IncRNA Perspective into (Re)Building the Heart. Front. Cell. Dev. Biol., 4. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2296-634X

Full text not available from this repository.

Abstract

Our conception of the human genome, long focused on the 2% that codes for proteins, has profoundly changed since its first draft assembly in 2001. Since then, an unanticipatedly expansive functionality and convolution has been attributed to the majority of the genome that is transcribed in a cell-type/context-specific manner into transcripts with no apparent protein coding ability. While the majority of these transcripts, currently annotated as long non coding RNAs (IncRNAs), are functionally uncharacterized, their prominent role in embryonic development and tissue homeostasis, especially in the context of the heart, is emerging. In this review, we summarize and discuss the latest advances in understanding the relevance of IncRNAs in (re)building the heart.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Frank, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Aguirre, Aitor UNSPECIFIED orcid.org/0000-0002-1383-2792 UNSPECIFIED Hescheler, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurian, Leo UNSPECIFIED orcid.org/0000-0001-7466-5169 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-292693
DOI:	10.3389/fcell.2016.00128
Journal or Publication Title:	Front. Cell. Dev. Biol.
Volume:	4
Date:	2016
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	2296-634X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG NONCODING RNA; LOCKED NUCLEIC-ACIDS; MESSENGER-RNA; CARDIAC-HYPERTROPHY; MAMMALIAN HEART; GENE-THERAPY; ANTISENSE; CELLS; OLIGONUCLEOTIDES; DIFFERENTIATION Multiple languages Cell Biology; Developmental Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29269