Universität zu Köln

Wolfsgruber, Steffen, Kleineidam, Luca, Wagner, Michael ORCID: 0000-0003-2589-6440, Moesch, Edelgard, Bickel, Horst, Luehmann, Dagmar, Ernst, Annette, Wiese, Birgitt, Steinmann, Susanne, Koenig, Hans-Helmut, Brettschneider, Christian ORCID: 0000-0002-5280-1075, Luck, Tobias ORCID: 0000-0001-7551-4397, Stein, Janine, Weyerer, Siegfried, Werle, Jochen, Pentzek, Michael, Fuchs, Angela, Maier, Wolfgang, Scherer, Martin, Riedel-Heller, Steffi G. and Jessen, Frank (2016). Differential Risk of Incident Alzheimer's Disease Dementia in Stable Versus Unstable Patterns of Subjective Cognitive Decline. J. Alzheimers Dis., 54 (3). S. 1135 - 1147. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

Background: It is unknown whether longitudinal stability versus instability in subjective cognitive decline (SCD) is a modifying factor of the association between SCD and risk of incident Alzheimer's disease (AD) dementia. Objective: We tested the modifying role of temporal stability of the SCD report on AD dementia risk in cognitively normal elderly individuals. Methods: We analyzed data of 1,990 cognitively normal participants from the longitudinal AgeCoDe Study. We assessed SCD with/without associated worries both at baseline and first follow-up 18 months later. Participants were then classified either as (a) Controls (CO, with no SCD at both baseline and follow-up 1, n = 613), (b) inconsistent SCD (with SCD reported only at baseline or at follow-up 1, n = 637), (c) consistent SCD but without/or with inconsistent worries (n = 610) or (d) consistent SCD with worries (n = 130). We estimated incident AD dementia risk over up to 6 years for each group with Cox-Proportional Hazard Regression analyses adjusted for age, gender, education, ApoE4 status, and depression. Results: Compared to CO, inconsistent SCD was not associated with increased risk of incident AD dementia. In contrast, risk was doubled in the group of consistent SCD without/with inconsistent worries, and almost 4-fold in the group of consistent SCD with worries. These results could be replicated when using follow-up 1 to follow-up 2 response patterns for group definition. Conclusion: These findings suggest that longitudinal stability versus instability is an important modifying factor of the association between SCD and AD dementia risk. Worrisome SCD that is also consistently reported over time is associated with greatly increased risk of AD dementia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wolfsgruber, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleineidam, Luca UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Moesch, Edelgard UNSPECIFIED UNSPECIFIED UNSPECIFIED Bickel, Horst UNSPECIFIED UNSPECIFIED UNSPECIFIED Luehmann, Dagmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Ernst, Annette UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiese, Birgitt UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinmann, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Hans-Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Brettschneider, Christian UNSPECIFIED orcid.org/0000-0002-5280-1075 UNSPECIFIED Luck, Tobias UNSPECIFIED orcid.org/0000-0001-7551-4397 UNSPECIFIED Stein, Janine UNSPECIFIED UNSPECIFIED UNSPECIFIED Weyerer, Siegfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Werle, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Pentzek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchs, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Scherer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel-Heller, Steffi G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-292830
DOI:	10.3233/JAD-160407
Journal or Publication Title:	J. Alzheimers Dis.
Volume:	54
Number:	3
Page Range:	S. 1135 - 1147
Date:	2016
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1875-8908
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MEMORY COMPLAINTS; OLDER-PEOPLE; IMPAIRMENT; ASSOCIATION; PROGRESSION; BIOMARKERS; MCI; PERSONALITY; PREVALENCE; REVERSION Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29283