Moinzadeh, Pia, Riemekasten, Gabriela, Siegert, Elise ORCID: 0000-0002-9594-0446, Fierlbeck, Gerhard, Henes, Joerg, Blank, Norbert, Melchers, Inga, Mueller-Ladner, Ulf, Frerix, Marc, Kreuter, Alexander, Tigges, Christian, Lahner, Nina, Susok, Laura, Guenther, Claudia, Zeidler, Gabriele, Pfeiffer, Christiane, Worm, Margitta, Karrer, Sigrid, Aberer, Elisabeth, Bretterklieber, Agnes, Genth, Ekkehard, Simon, Jan C., Distler, Joerg H. W., Hein, Ruediger, Schneider, Matthias, Seitz, Cornelia S., Herink, Claudia, Steinbrink, Kerstin, Sardy, Miklos, Varga, Rita, Mensing, Hartwig, Mensing, Christian, Lehmann, Percy, Neeck, Gunther, Fiehn, Christoph, Weber, Manfred, Goebeler, Matthias, Burkhardt, Harald, Buslau, Michael, Ahmadi-Simab, Keihan, Himsel, Andrea, Juche, Aaron, Koetter, Ina ORCID: 0000-0002-9262-005X, Kuhn, Annegret, Sticherling, Michael, Hellmich, Martin, Kuhr, Kathrin, Krieg, Thomas, Ehrchen, Jan, Sunderkoetter, Cord and Hunzelmann, Nicolas (2016). Vasoactive Therapy in Systemic Sclerosis: Real-life Therapeutic Practice in More Than 3000 Patients. J. Rheumatol., 43 (1). S. 66 - 75. TORONTO: J RHEUMATOL PUBL CO. ISSN 1499-2752

Full text not available from this repository.

Abstract

Objective. Vasculopathy is a key factor in the pathophysiology of systemic sclerosis (SSc) and the main cause for Raynaud phenomenon (RP), digital ulcers (DU), and/or pulmonary arterial hypertension (PAH). It is so far unknown how patients with SSc are treated with vasoactive agents in daily practice. To determine to which extent patients with SSc were treated with different vasoactive agents, we used data from the German Network for Systemic Scleroderma registry. Methods. The data of 3248 patients with SSc were analyzed. Results. Patients were treated with vasoactive drugs in 61.1% of cases (1984/3248). Of these, 47.6% received calcium channel inhibitors, followed by 34.2% treated with angiotensin-converting enzyme (ACE) inhibitors, 21.1% treated with intravenous (IV) prostanoids, 10.1% with pentoxifylline, 8.8% with angiotensin 1 receptor antagonists (AT1RA), 8.7% with endothelin 1 receptor antagonists (ET1RA), 4.1% with phosphodiesterase type 5 (PDE5) inhibitors, and 5.3% with others. Patients with RP received vasoactive therapy in 63.3% of cases, with DU in 70.1%, and with PAH in 78.2% of cases. Logistic regression analysis revealed that patients with PAH were significantly more often treated with PDE5 inhibitors and ET1RA, and those with DU with ET1RA and IV prostanoids. In addition, 41.8% of patients were treated with ACE inhibitors and/or AT1RA. Patients registered after 2009 received significantly more often ET1RA, AT1RA, and IV prostanoids compared with patients registered prior to 2005. Conclusion. These data clearly indicate that many patients with SSc do not yet receive sufficient vasoactive therapy. Further, in recent years, a marked change of treatment regimens can be observed.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Moinzadeh, PiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riemekasten, GabrielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siegert, EliseUNSPECIFIEDorcid.org/0000-0002-9594-0446UNSPECIFIED
Fierlbeck, GerhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henes, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blank, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Melchers, IngaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller-Ladner, UlfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frerix, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreuter, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tigges, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lahner, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Susok, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guenther, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeidler, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfeiffer, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Worm, MargittaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karrer, SigridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aberer, ElisabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bretterklieber, AgnesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Genth, EkkehardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simon, Jan C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Distler, Joerg H. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hein, RuedigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seitz, Cornelia S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herink, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinbrink, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sardy, MiklosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Varga, RitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mensing, HartwigUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mensing, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehmann, PercyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neeck, GuntherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fiehn, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, ManfredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goebeler, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burkhardt, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buslau, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ahmadi-Simab, KeihanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Himsel, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Juche, AaronUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koetter, InaUNSPECIFIEDorcid.org/0000-0002-9262-005XUNSPECIFIED
Kuhn, AnnegretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sticherling, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hellmich, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuhr, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krieg, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ehrchen, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sunderkoetter, CordUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hunzelmann, NicolasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-292960
DOI: 10.3899/jrheum.150382
Journal or Publication Title: J. Rheumatol.
Volume: 43
Number: 1
Page Range: S. 66 - 75
Date: 2016
Publisher: J RHEUMATOL PUBL CO
Place of Publication: TORONTO
ISSN: 1499-2752
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PULMONARY ARTERIAL-HYPERTENSION; ENDOTHELIN RECEPTOR ANTAGONIST; DIGITAL ULCERS; RAYNAUDS-PHENOMENON; VASCULAR COMPLICATIONS; CONTROLLED-TRIAL; GERMAN NETWORK; DOUBLE-BLIND; SCLERODERMA; MANAGEMENTMultiple languages
RheumatologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/29296

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item