Universität zu Köln

Li, Yuxia, Wang, Xiaoni, Li, Yongqiu, Sun, Yu, Sheng, Can, Li, Hongyan, Li, Xuanyu, Yu, Yang, Chen, Guanqun, Hu, Xiaochen, Jing, Bin, Wang, Defeng, Li, Kuncheng, Jessen, Frank, Xia, Mingrui ORCID: 0000-0003-4615-9132 and Han, Ying (2016). Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer's Disease. Neural. Plast., 2016. LONDON: HINDAWI LTD. ISSN 1687-5443

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Abstract

Individuals diagnosed with mild cognitive impairment (MCI) are at high risk of transition to Alzheimer's disease (AD). However, little is known about functional characteristics of the conversion from MCI to AD. Resting-state functional magnetic resonance imaging was performed in 25 AD patients, 31 MCI patients, and 42 well-matched normal controls at baseline. Twenty-one of the 31 MCI patients converted to AD at approximately 24 months of follow-up. Functional connectivity strength (FCS) and seed-based functional connectivity analyses were used to assess the functional differences among the groups. Compared to controls, subjects with MCI and AD showed decreased FCS in the default-mode network and the occipital cortex. Importantly, the FCS of the left angular gyrus and middle occipital gyrus was significantly lower in MCI-converters as compared with MCI-nonconverters. Significantly decreased functional connectivity was found in MCI-converters compared to nonconverters between the left angular gyrus and bilateral inferior parietal lobules, dorsolateral prefrontal and lateral temporal cortices, and the left middle occipital gyrus and right middle occipital gyri. We demonstrated gradual but progressive functional changes during a median 2-year interval in patients converting from MCI to AD, which might serve as early indicators for the dysfunction and progression in the early stage of AD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Li, Yuxia UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Xiaoni UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Yongqiu UNSPECIFIED UNSPECIFIED UNSPECIFIED Sun, Yu UNSPECIFIED UNSPECIFIED UNSPECIFIED Sheng, Can UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Hongyan UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Xuanyu UNSPECIFIED UNSPECIFIED UNSPECIFIED Yu, Yang UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Guanqun UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Xiaochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Jing, Bin UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Defeng UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Kuncheng UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Xia, Mingrui UNSPECIFIED orcid.org/0000-0003-4615-9132 UNSPECIFIED Han, Ying UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-293175
DOI:	10.1155/2016/4680972
Journal or Publication Title:	Neural. Plast.
Volume:	2016
Date:	2016
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	1687-5443
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CEREBRAL-BLOOD-FLOW; DEFAULT-MODE; GLOBAL SIGNAL; PARIETAL LOBE; NETWORK HUBS; HEAD MOTION; BRAIN; FMRI; INDIVIDUALS; POPULATION Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29317