Universität zu Köln

Papazoglou, Anna, Soos, Julien, Lundt, Andreas, Wormuth, Carola, Ginde, Varun Raj, Mueller, Ralf, Henseler, Christina, Broich, Karl, Xie, Kan, Ehninger, Dan, Haenisch, Britta and Weiergraber, Marco (2016). Gender-Specific Hippocampal Dysrhythmia and Aberrant Hippocampal and Cortical Excitability in the APPswePS1dE9 Model of Alzheimer's Disease. Neural. Plast., 2016. LONDON: HINDAWI LTD. ISSN 1687-5443

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Abstract

Alzheimer's disease (AD) is a multifactorial disorder leading to progressive memory loss and eventually death. In this study an APPswePS1dE9 AD mouse model has been analyzed using implantable video-EEG radiotelemetry to perform long-term EEG recordings from the primary motor cortex M1 and the hippocampal CA1 region in both genders. Besides motor activity, EEG recordings were analyzed for electroencephalographic seizure activity and frequency characteristics using a Fast Fourier Transformation (FFT) based approach. Automatic seizure detection revealed severe electroencephalographic seizure activity in both M1 and CA1 deflection in APPswePS1dE9 mice with gender-specific characteristics. Frequency analysis of both surface and deep EEG recordings elicited complex age, gender, and activity dependent alterations in the theta and gamma range. Females displayed an antithetic decrease in theta (theta) and increase in gamma (theta) power at 18-19 weeks of age whereas related changes in males occurred earlier at 14 weeks of age. In females, theta (theta) and gamma (theta) power alterations predominated in the inactive state suggesting a reduction in atropine-sensitive type II theta in APPswePS1dE9 animals. Gender-specific central dysrhythmia and network alterations in APPswePS1dE9 point to a functional role in behavioral and cognitive deficits and might serve as early biomarkers for AD in the future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Papazoglou, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Soos, Julien UNSPECIFIED UNSPECIFIED UNSPECIFIED Lundt, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Wormuth, Carola UNSPECIFIED UNSPECIFIED UNSPECIFIED Ginde, Varun Raj UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Henseler, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Broich, Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Xie, Kan UNSPECIFIED UNSPECIFIED UNSPECIFIED Ehninger, Dan UNSPECIFIED UNSPECIFIED UNSPECIFIED Haenisch, Britta UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiergraber, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-293185
DOI:	10.1155/2016/7167358
Journal or Publication Title:	Neural. Plast.
Volume:	2016
Date:	2016
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	1687-5443
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language THETA RHYTHM HETEROGENEITY; MILD COGNITIVE IMPAIRMENT; BETA-AMYLOID PROTEIN; MOUSE MODEL; NETWORK OSCILLATIONS; INDUCED NEURODEGENERATION; TRANSGENIC MOUSE; SEX-DIFFERENCES; EEG; NEURONS Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29318