Universität zu Köln

Sigaroudi, Ali ORCID: 0000-0002-3176-4631, Stelzer, Christoph, Braun, Tina, Frechen, Sebastian, Huettner, Sven, Schroeter, Michael, Kinzig, Martina, Fuhr, Uwe, Holzgrabe, Ulrike ORCID: 0000-0002-0364-7278 and Soergel, Fritz (2016). Comparison of Pantoprazole Concentrations in Simultaneous Cerebrospinal Fluid and Serum Samples. Pharmacology, 98 (1-2). S. 70 - 73. BASEL: KARGER. ISSN 1423-0313

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Abstract

Background: Pantoprazole is a proton pump inhibitor drug mainly used for treating peptic diseases. Adverse effects of pantoprazole in the occasional central nervous system (CNS) include headache, vertigo and sleep disturbances. Data in rats suggest that proton pumps are expressed in the inner ear and in the epithelium of the choroid plexus, which would be a potential target to mediate such proton pump inhibitor effects. Methods: To assess the distribution of pantoprazole into the human CNS despite its low lipophilicity (log p = 0.5), we quantified pantoprazole concentrations by liquid chromatography/tandem mass spectrometry in serum and cerebrospinal fluid retain samples withdrawn simultaneously. Twenty-six sample pairs were obtained from 23 neurological patients with therapeutic administration of pantoprazole prior to sampling. Results: Median (interquartile range) serum concentration of total pantoprazole was 142 ng/ml (30.8-622). Cerebrospinal fluid concentration of total panto-prazole was 2.79 ng/ml (1.59-7.3) and reached 2.0% (1.04.5%) of simultaneous serum concentrations. Conclusion: This value corresponds to the unbound fraction of pantoprazole in serum reported previously and indicates that pantoprazole CNS concentrations are high enough to exert some effects on possible CNS targets. (C) 2016 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sigaroudi, Ali UNSPECIFIED orcid.org/0000-0002-3176-4631 UNSPECIFIED Stelzer, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Braun, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED Frechen, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Huettner, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Kinzig, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuhr, Uwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Holzgrabe, Ulrike UNSPECIFIED orcid.org/0000-0002-0364-7278 UNSPECIFIED Soergel, Fritz UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-293303
DOI:	10.1159/000445720
Journal or Publication Title:	Pharmacology
Volume:	98
Number:	1-2
Page Range:	S. 70 - 73
Date:	2016
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0313
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROTON PUMP INHIBITORS Multiple languages Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29330