Universität zu Köln

Schloemer, Nasim, Lenz, Melanie, Tegenthoff, Martin, Dinse, Hubert R. and Hoeffken, Oliver (2020). Parallel modulation of intracortical excitability of somatosensory and visual cortex by the gonadal hormones estradiol and progesterone. Sci Rep, 10 (1). BERLIN: NATURE RESEARCH. ISSN 2045-2322

Full text not available from this repository.

Abstract

The levels of the gonadal hormones estradiol and progesterone vary throughout the menstrual cycle thereby affecting cognition, emotion, mood, and social behaviour. However, how these hormones modulate the balance of neural excitation and inhibition, which crucially regulate processing and plasticity, is not fully understood. We here used paired-pulse stimulation to investigate in healthy humans the action of low and high estradiol and progesterone on intracortical inhibition in somatosensory (SI) and visual cortex (V1). We found that paired-pulse suppression in both SI and VI depended on estradiol. During high estradiol levels, paired-pulse suppression was significantly reduced. No comparable effects were found for progesterone, presumably due to a confounding effect of estradiol. Also, no hormone level-depending effects were observed for single-pulse evoked SEPs (somatosensory evoked potentials) and VEPs (visual evoked potentials) indicating a specific hormonal action on intracortical processing. The results demonstrate that estradiol globally modulates the balance of excitation and inhibition of SI and VI cortex.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schloemer, Nasim UNSPECIFIED UNSPECIFIED UNSPECIFIED Lenz, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Tegenthoff, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Dinse, Hubert R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoeffken, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-307802
DOI:	10.1038/s41598-020-79389-6
Journal or Publication Title:	Sci Rep
Volume:	10
Number:	1
Date:	2020
Publisher:	NATURE RESEARCH
Place of Publication:	BERLIN
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; PAIRED-PULSE-SUPPRESSION; MEDIAN NERVE-STIMULATION; EVOKED-POTENTIALS; CORTICAL EXCITABILITY; MENSTRUAL-CYCLE; SYNAPTIC MECHANISMS; OVARIAN HORMONES; MOTOR CORTEX; INHIBITION Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/30780