Universität zu Köln

Richter, Fabian, Garcia, Adolfo M., Rodriguez Arriagada, Nicolas, Yoris, Adrian, Birba, Agustina, Huepe, David, Zimmer, Heinz, Ibanez, Agustin ORCID: 0000-0001-6758-5101 and Sedeno, Lucas . Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation. Hum. Brain Mapp.. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

An accruing body of research has shown that interoception (the sensing of signals from the body's internal milieu) relies on both a direct route (afforded by the vagus nerve) and a secondary route (supported by somatosensory mechanisms). However, no study has causally tested the differential role of these pathways, let alone via direct stimulation. To bridge this gap, we tested whether multidimensional signatures of interoception are modulated by noninvasive vagus nerve stimulation (nVNS). Sixty-three participants were divided into an nVNS and a sham-stimulation group. Before and after stimulation, both groups performed a validated heartbeat detection (HBD) task including a genuinely interoceptive condition (monitoring one's own heartbeat) and a control exteroceptive condition (tracking an aurally presented heartbeat). Electroencephalographic signals were obtained during both conditions to examine modulations of the heartbeat-evoked potential (HEP). Moreover, before and after stimulation, participants were asked to complete a somatosensory heartbeat localization task. Results from the interoceptive condition revealed that, after treatment, only the nVNS group exhibited improved performance and greater HEP modulations. No behavioral differences were found for the exteroceptive control condition, which was nonetheless associated with significant HEP modulations. Finally, no between-group differences were observed regarding the localization of the heartbeat sensations or relevant cardiodynamic variables (heart rate and or heart rate variability). Taken together, these results constitute unprecedented evidence that the vagus nerve plays a direct role in neurovisceral integration during interoception. This finding can constrain mechanistic models of the domain while informing a promising transdiagnostic agenda for interoceptive impairments across neuropsychiatric conditions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Richter, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia, Adolfo M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rodriguez Arriagada, Nicolas UNSPECIFIED UNSPECIFIED UNSPECIFIED Yoris, Adrian UNSPECIFIED UNSPECIFIED UNSPECIFIED Birba, Agustina UNSPECIFIED UNSPECIFIED UNSPECIFIED Huepe, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmer, Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Ibanez, Agustin UNSPECIFIED orcid.org/0000-0001-6758-5101 UNSPECIFIED Sedeno, Lucas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-307952
DOI:	10.1002/hbm.25288
Journal or Publication Title:	Hum. Brain Mapp.
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEARTBEAT EVOKED-POTENTIALS; ELECTRICAL-STIMULATION; INDIVIDUAL-DIFFERENCES; CARDIAC AWARENESS; BRAIN POTENTIALS; NEURAL MARKERS; FMRI EVIDENCE; RATE FEEDBACK; PERCEPTION; METAANALYSIS Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/30795