Betz, Linda T., Penzel, Nora, Kambeitz-Ilankovic, Lana, Rosen, Marlene, Chisholm, Katharine ORCID: 0000-0002-0575-0789, Stainton, Alexandra, Haidl, Theresa K., Wenzel, Julian, Bertolino, Alessandro, Borgwardt, Stefan, Brambilla, Paolo, Lencer, Rebekka, Meisenzahl, Eva, Ruhrmann, Stephan, Salokangas, Raimo K. R., Schultze-Lutter, Frauke, Wood, Stephen J., Upthegrove, Rachel, Koutsouleris, Nikolaos and Kambeitz, Joseph (2020). General psychopathology links burden of recent life events and psychotic symptoms in a network approach. npj Schizophr., 6 (1). BERLIN: NATURE RESEARCH. ISSN 2334-265X

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Abstract

Recent life events have been implicated in the onset and progression of psychosis. However, psychological processes that account for the association are yet to be fully understood. Using a network approach, we aimed to identify pathways linking recent life events and symptoms observed in psychosis. Based on previous literature, we hypothesized that general symptoms would mediate between recent life events and psychotic symptoms. We analyzed baseline data of patients at clinical high risk for psychosis and with recent-onset psychosis (n = 547) from the Personalised Prognostic Tools for Early Psychosis Management (PRONIA) study. In a network analysis, we modeled links between the burden of recent life events and all individual symptoms of the Positive and Negative Syndrome Scale before and after controlling for childhood trauma. To investigate the longitudinal associations between burden of recent life events and symptoms, we analyzed multiwave panel data from seven timepoints up to month 18. Corroborating our hypothesis, burden of recent life events was connected to positive and negative symptoms through general psychopathology, specifically depression, guilt feelings, anxiety and tension, even after controlling for childhood trauma. Longitudinal modeling indicated that on average, burden of recent life events preceded general psychopathology in the individual. In line with the theory of an affective pathway to psychosis, recent life events may lead to psychotic symptoms via heightened emotional distress. Life events may be one driving force of unspecific, general psychopathology described as characteristic of early phases of the psychosis spectrum, offering promising avenues for interventions.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Betz, Linda T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Penzel, NoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz-Ilankovic, LanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosen, MarleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chisholm, KatharineUNSPECIFIEDorcid.org/0000-0002-0575-0789UNSPECIFIED
Stainton, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haidl, Theresa K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wenzel, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bertolino, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgwardt, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brambilla, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lencer, RebekkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meisenzahl, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhrmann, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salokangas, Raimo K. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schultze-Lutter, FraukeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wood, Stephen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Upthegrove, RachelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koutsouleris, NikolaosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-308103
DOI: 10.1038/s41537-020-00129-w
Journal or Publication Title: npj Schizophr.
Volume: 6
Number: 1
Date: 2020
Publisher: NATURE RESEARCH
Place of Publication: BERLIN
ISSN: 2334-265X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CHILDHOOD TRAUMA; HIGH-RISK; STRESS-REACTIVITY; POSITIVE SYMPTOMS; DEPRESSION; SCHIZOPHRENIA; ADVERSITY; ONSET; INDIVIDUALS; ASSOCIATIONMultiple languages
PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/30810

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