Universität zu Köln

Llamas, Ernesto, Alirzayeva, Hafiza, Loureiro, Rute and Vilchez, David (2020). The intrinsic proteostasis network of stem cells. Curr. Opin. Cell Biol., 67. S. 46 - 56. LONDON: CURRENT BIOLOGY LTD. ISSN 1879-0410

Full text not available from this repository.

Abstract

The proteostasis network adjusts protein composition and maintains protein integrity, which are essential processes for cell function and viability. Current efforts, given their intrinsic characteristics, regenerative potential and fundamental biological functions, have been directed to define proteostasis of stem cells. These insights demonstrate that embryonic stem cells and induced pluripotent stem cells exhibit an endogenous proteostasis network that not only modulates their pluripotency and differentiation but also provides a striking ability to suppress aggregation of disease-related proteins. Moreover, recent findings establish a central role of enhanced proteostasis to prevent the aging of somatic stem cells in adult organisms. Notably, proteostasis is also required for the biological purpose of adult germline stem cells, that is to be passed from one generation to the next. Beyond these links between proteostasis and stem cell function, we also discuss the implications of these findings for disease, aging, and reproduction.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Llamas, Ernesto UNSPECIFIED UNSPECIFIED UNSPECIFIED Alirzayeva, Hafiza UNSPECIFIED UNSPECIFIED UNSPECIFIED Loureiro, Rute UNSPECIFIED UNSPECIFIED UNSPECIFIED Vilchez, David UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-309385
DOI:	10.1016/j.ceb.2020.08.005
Journal or Publication Title:	Curr. Opin. Cell Biol.
Volume:	67
Page Range:	S. 46 - 56
Date:	2020
Publisher:	CURRENT BIOLOGY LTD
Place of Publication:	LONDON
ISSN:	1879-0410
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AUTOPHAGY MAINTAINS; STRESS DEFENSE; PLURIPOTENCY; MECHANISMS; PROTEASOME; DIFFERENTIATION; PROTEINS; REPRODUCTION; FIBROBLASTS; HOMEOSTASIS Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/30938