Universität zu Köln

Kronsbein, Hendrik, Gerlach, Darius A., Heusser, Karsten, Hoff, Alex, Hoffmann, Fabian ORCID: 0000-0002-3199-9924, Diedrich, Andre, Ehmke, Heimo, Jordan, Jens and Tank, Jens (2020). Testing individual baroreflex responses to hypoxia-induced peripheral chemoreflex stimulation. Clin. Auton. Res., 30 (6). S. 531 - 541. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1619-1560

Full text not available from this repository.

Abstract

Introduction Baroreflexes and peripheral chemoreflexes control efferent autonomic activity making these reflexes treatment targets for arterial hypertension. The literature on their interaction is controversial, with suggestions that their individual and collective influence on blood pressure and heart rate regulation is variable. Therefore, we applied a study design that allows the elucidation of individual baroreflex-chemoreflex interactions. Methods We studied nine healthy young men who breathed either normal air (normoxia) or an air-nitrogen-carbon dioxide mixture with decreased oxygen content (hypoxia) for 90 min, with randomization to condition, followed by a 30-min recovery period and then exposure to the other condition for 90 min. Multiple intravenous phenylephrine bolus doses were applied per condition to determine phenylephrine pressor sensitivity as an estimate of baroreflex blood pressure buffering and cardiovagal baroreflex sensitivity (BRS). Results Hypoxia reduced arterial oxygen saturation from 98.1 +/- 0.4 to 81.0 +/- 0.4% (p < 0.001), raised heart rate from 62.9 +/- 2.1 to 76.0 +/- 3.6 bpm (p < 0.001), but did not change systolic blood pressure (p = 0.182). Of the nine subjects, six had significantly lower BRS in hypoxia (p < 0.05), two showed a significantly decreased pressor response, and three showed a significantly increased pressor response to phenylephrine in hypoxia, likely through reduced baroreflex buffering (p < 0.05). On average, hypoxia decreased BRS by 6.4 +/- 0.9 ms/mmHg (19.9 +/- 2.0 vs. 14.12 +/- 1.6 ms/mmHg; p < 0.001) but did not change the phenylephrine pressor response (p = 0.878). Conclusion We applied an approach to assess individual baroreflex-chemoreflex interactions in human subjects. A subgroup exhibited significant impairments in baroreflex blood pressure buffering and BRS with peripheral chemoreflex activation. The methodology may have utility in elucidating individual pathophysiology and in targeting treatments modulating baroreflex or chemoreflex function.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kronsbein, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerlach, Darius A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heusser, Karsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoff, Alex UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Fabian UNSPECIFIED orcid.org/0000-0002-3199-9924 UNSPECIFIED Diedrich, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Ehmke, Heimo UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Tank, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-310201
DOI:	10.1007/s10286-019-00660-6
Journal or Publication Title:	Clin. Auton. Res.
Volume:	30
Number:	6
Page Range:	S. 531 - 541
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1619-1560
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SYMPATHETIC-NERVE ACTIVITY; CAROTID-BODY; BLOOD-PRESSURE; RESISTANT HYPERTENSION; HEART-RATE; YOUNG MEN; CHEMORECEPTOR; SENSITIVITY; ACTIVATION; BARORECEPTOR Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31020