Dominguez-Valentin, Mev ORCID: 0000-0001-7856-0057, Crosbie, Emma J., Engel, Christoph, Aretz, Stefan, Macrae, Finlay, Winship, Ingrid, Capella, Gabriel, Thomas, Huw, Nakken, Sigve ORCID: 0000-0001-8468-2050, Hovig, Eivind, Nielsen, Maartje, Sijmons, Rolf H., Bertario, Lucio, Bonanni, Bernardo, Tibiletti, Maria Grazia, Cavestro, Giulia Martina, Mints, Miriam, Gluck, Nathan, Katz, Lior, Heinimann, Karl, Vaccaro, Carlos A., Green, Kate, Lalloo, Fiona, Hill, James, Schmiegel, Wolff, Vangala, Deepak, Perne, Claudia, Strauss, Hans-Georg, Tecklenburg, Johanna, Holinski-Feder, Elke, Steinke-Lange, Verena, Mecklin, Jukka-Pekka, Plazzer, John-Paul, Pineda, Marta, Navarro, Matilde, Brunet Vidal, Joan, Kariv, Revital, Rosner, Guy, Alejandra Pinero, Tamara, Laura Gonzalez, Maria, Kalfayan, Pablo, Ryan, Neil, Ten Broeke, Sanne W., Jenkins, Mark A., Sunde, Lone, Bernstein, Inge, Burn, John, Greenblatt, Marc, Cappel, Wouter H. de Vos tot Nederveen, Della Valle, Adriana, Lopez-Koestner, Francisco, Alvarez, Karin, Buettner, Reinhard, Goergens, Heike, Morak, Monika, Holzapfel, Stefanie, Hueneburg, Robert, Doeberitz, Magnus von Knebel, Loeffler, Markus, Rahner, Nils, Weitz, Jurgen, Pylvanainen, Kirsi ORCID: 0000-0003-4399-9283, Renkonen-Sinisalo, Laura, Lepisto, Anna, Auranen, Annika, Hopper, John L., Win, Aung Ko, Haile, Robert W., Lindor, Noralane M., Gallinger, Steven, Le Marchand, Loic, Newcomb, Polly A., Figueiredo, Jane C., Thibodeau, Stephen N., Therkildsen, Christina, Okkels, Henrik, Ketabi, Zohreh, Denton, Oliver G., Rodland, Einar Andreas, Vasen, Hans, Neffa, Florencia, Esperon, Patricia, Tjandra, Douglas, Moeslein, Gabriela, Sampson, Julian R., Evans, D. Gareth, Seppala, Toni T. and Moller, Pal . Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report. Genet. Med.. LONDON: SPRINGERNATURE. ISSN 1530-0366

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Abstract

Purpose To determine impact of risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) on gynecological cancer incidence and death in heterozygotes of pathogenic MMR (path_MMR) variants. Methods The Prospective Lynch Syndrome Database was used to investigate the effects of gynecological risk-reducing surgery (RRS) at different ages. Results Risk-reducing hysterectomy at 25 years of age prevents endometrial cancer before 50 years in 15%, 18%, 13%, and 0% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 heterozygotes and death in 2%, 2%, 1%, and 0%, respectively. Risk-reducing BSO at 25 years of age prevents ovarian cancer before 50 years in 6%, 11%, 2%, and 0% and death in 1%, 2%, 0%, and 0%, respectively. Risk-reducing hysterectomy at 40 years prevents endometrial cancer by 50 years in 13%, 16%, 11%, and 0% and death in 1%, 2%, 1%, and 0%, respectively. BSO at 40 years prevents ovarian cancer before 50 years in 4%, 8%, 0%, and 0%, and death in 1%, 1%, 0%, and 0%, respectively. Conclusion Little benefit is gained by performing RRS before 40 years of age and premenopausal BSO in path_MSH6 and path_PMS2 heterozygotes has no measurable benefit for mortality. These findings may aid decision making for women with LS who are considering RRS.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Dominguez-Valentin, MevUNSPECIFIEDorcid.org/0000-0001-7856-0057UNSPECIFIED
Crosbie, Emma J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engel, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aretz, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Macrae, FinlayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winship, IngridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Capella, GabrielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thomas, HuwUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nakken, SigveUNSPECIFIEDorcid.org/0000-0001-8468-2050UNSPECIFIED
Hovig, EivindUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nielsen, MaartjeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sijmons, Rolf H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bertario, LucioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonanni, BernardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tibiletti, Maria GraziaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cavestro, Giulia MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mints, MiriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gluck, NathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katz, LiorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinimann, KarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vaccaro, Carlos A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Green, KateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lalloo, FionaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hill, JamesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmiegel, WolffUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vangala, DeepakUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perne, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strauss, Hans-GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tecklenburg, JohannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holinski-Feder, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinke-Lange, VerenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mecklin, Jukka-PekkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plazzer, John-PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pineda, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Navarro, MatildeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brunet Vidal, JoanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kariv, RevitalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosner, GuyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alejandra Pinero, TamaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laura Gonzalez, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalfayan, PabloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ryan, NeilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ten Broeke, Sanne W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jenkins, Mark A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sunde, LoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bernstein, IngeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burn, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Greenblatt, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cappel, Wouter H. de Vos tot NederveenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Della Valle, AdrianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopez-Koestner, FranciscoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alvarez, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buettner, ReinhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goergens, HeikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morak, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holzapfel, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hueneburg, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doeberitz, Magnus von KnebelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loeffler, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rahner, NilsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weitz, JurgenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pylvanainen, KirsiUNSPECIFIEDorcid.org/0000-0003-4399-9283UNSPECIFIED
Renkonen-Sinisalo, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lepisto, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Auranen, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hopper, John L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Win, Aung KoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haile, Robert W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindor, Noralane M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gallinger, StevenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le Marchand, LoicUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Newcomb, Polly A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Figueiredo, Jane C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thibodeau, Stephen N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Therkildsen, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Okkels, HenrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ketabi, ZohrehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Denton, Oliver G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodland, Einar AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vasen, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neffa, FlorenciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Esperon, PatriciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tjandra, DouglasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moeslein, GabrielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sampson, Julian R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, D. GarethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seppala, Toni T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moller, PalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-310215
DOI: 10.1038/s41436-020-01029-1
Journal or Publication Title: Genet. Med.
Publisher: SPRINGERNATURE
Place of Publication: LONDON
ISSN: 1530-0366
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HEREDITARY COLORECTAL-CANCER; ASPIRIN; CAPP2Multiple languages
Genetics & HeredityMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31021

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