Cremer, Sebastian, Jakob, Carolin, Berkowitsch, Alexander, Borgmann, Stefan, Pilgram, Lisa, Tometten, Lukas, Classen, Annika, Wille, Kai ORCID: 0000-0002-7682-8563, Weidlich, Simon, Gruener, Beate, Dimmeler, Stefanie, Massberg, Steffen, Rieg, Siegbert and Zeiher, Andreas M. . Elevated markers of thrombo-inflammatory activation predict outcome in patients with cardiovascular comorbidities and COVID-19 disease: insights from the LEOSS registry. Clin. Res. Cardiol.. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1861-0692

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Abstract

Aims: SARS-CoV-2 infection is associated with adverse outcomes in patients with cardiovascular disease. Here, we analyzed whether specific biomarkers predict the clinical course of COVID-19 in patients with cardiovascular comorbidities. Methods and results: We enrolled 2147 patients with SARS-CoV-2 infection which were included in the Lean European Open Survey on SARS-CoV-2 (LEOSS)-registry from March to June 2020. Clinical data and laboratory values were collected and compared between patients with and without cardiovascular comorbidities in different clinical stages of the disease. Predictors for mortality were calculated using multivariate regression analysis. We show that patients with cardiovascular comorbidities display significantly higher markers of myocardial injury and thrombo-inflammatory activation already in the uncomplicated phase of COVID-19. In multivariate analysis, elevated levels of troponin [OR 1.54; (95% CI 1.22-1.96), p < 0.001)], IL-6 [OR 1.69 (95% CI 1.26-2.27), p < 0.013)], and CRP [OR 1.32; (95% CI 1.1-1.58), p < 0.003)] were predictors of mortality in patients with COVID-19. Conclusion: Patients with cardiovascular comorbidities show elevated markers of thrombo-inflammatory activation and myocardial injury, which predict mortality, already in the uncomplicated phase of COVID-19. Starting targeted anti-inflammatory therapy and aggressive anticoagulation already in the uncomplicated phase of the disease might improve outcomes after SARS-CoV-2 infection in patients with cardiovascular comorbidities. Graphic abstract: Elevated markers of thrombo-inflammatory activation predict outcome in patients with cardiovascular comorbidities and COVID-19 disease: insights from the LEOSS registry [GRAPHICS] .

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Cremer, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jakob, CarolinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berkowitsch, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgmann, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pilgram, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tometten, LukasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Classen, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wille, KaiUNSPECIFIEDorcid.org/0000-0002-7682-8563UNSPECIFIED
Weidlich, SimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruener, BeateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dimmeler, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Massberg, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rieg, SiegbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeiher, Andreas M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-311099
DOI: 10.1007/s00392-020-01769-9
Journal or Publication Title: Clin. Res. Cardiol.
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1861-0692
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Cardiac & Cardiovascular SystemsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31109

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