Universität zu Köln

Walger, Helene, Antonucci, Linda A., Pigoni, Alessandro, Upthegrove, Rachel, Salokangas, Raimo K. R., Lencer, Rebekka, Chisholm, Katharine ORCID: 0000-0002-0575-0789, Riecher-Rossler, Anita, Haidl, Theresa, Meisenzahl, Eva, Rosen, Marlene, Ruhrmann, Stephan, Kambeitz, Joseph, Kambeitz-Ilankovic, Lana, Falkai, Peter, Ruef, Anne, Hietala, Jarmo, Pantelis, Christos, Wood, Stephen J., Brambilla, Paolo, Bertolino, Alessandro, Borgwardt, Stefan, Koutsouleris, Nikolaos and Schultze-Lutter, Frauke (2020). Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study. Front. Psychiatry, 11. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-0640

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Abstract

In community studies, both attenuated psychotic symptoms (APS) and basic symptoms (BS) were more frequent but less clinically relevant in children and adolescents compared to adults. In doing so, they displayed differential age thresholds that were around age 16 for APS, around age 18 for perceptive BS, and within the early twenties for cognitive BS. Only the age effect has previously been studied and replicated in clinical samples for APS. Thus, we examined the reported age effect on and age thresholds of 14 criteria-relevant BS in a patient sample at clinical-high risk of psychosis (N = 261, age 15-40 yrs.), recruited within the European multicenter PRONIA-study. BS and the BS criteria, Cognitive Disturbances (COGDIS) and Cognitive-perceptive BS (COPER), were assessed with the Schizophrenia Proneness Instrument, Adult version (SPI-A). Using logistic regressions, prevalence rates of perceptive and cognitive BS, and of COGDIS and COPER, as well as the impact of social and role functioning on the association between age and BS were studied in three age groups (15-18 years, 19-23 years, 24-40 years). Most patients (91.2%) reported any BS, 55.9% any perceptive and 87.4% any cognitive BS. Furthermore, 56.3% met COGDIS and 80.5% COPER. Not exhibiting the reported differential age thresholds, both perceptive and cognitive BS, and, at trend level only, COPER were less prevalent in the oldest age group (24-40 years); COGDIS was most frequent in the youngest group (15-18 years). Functional deficits did not better explain the association with age, particularly in perceptive BS and cognitive BS meeting the frequency requirement of BS criteria. Our findings broadly confirmed an age threshold in BS and, thus, the earlier assumed link between presence of BS and brain maturation processes. Yet, age thresholds of perceptive and cognitive BS did not differ. This lack of differential age thresholds might be due to more pronounced the brain abnormalities in this clinical sample compared to earlier community samples. These might have also shown in more frequently occurring and persistent BS that, however, also resulted from a sampling toward these, i.e., toward COGDIS. Future studies should address the neurobiological basis of CHR criteria in relation to age.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Walger, Helene UNSPECIFIED UNSPECIFIED UNSPECIFIED Antonucci, Linda A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pigoni, Alessandro UNSPECIFIED UNSPECIFIED UNSPECIFIED Upthegrove, Rachel UNSPECIFIED UNSPECIFIED UNSPECIFIED Salokangas, Raimo K. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lencer, Rebekka UNSPECIFIED UNSPECIFIED UNSPECIFIED Chisholm, Katharine UNSPECIFIED orcid.org/0000-0002-0575-0789 UNSPECIFIED Riecher-Rossler, Anita UNSPECIFIED UNSPECIFIED UNSPECIFIED Haidl, Theresa UNSPECIFIED UNSPECIFIED UNSPECIFIED Meisenzahl, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosen, Marlene UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhrmann, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Kambeitz, Joseph UNSPECIFIED UNSPECIFIED UNSPECIFIED Kambeitz-Ilankovic, Lana UNSPECIFIED UNSPECIFIED UNSPECIFIED Falkai, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruef, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Hietala, Jarmo UNSPECIFIED UNSPECIFIED UNSPECIFIED Pantelis, Christos UNSPECIFIED UNSPECIFIED UNSPECIFIED Wood, Stephen J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brambilla, Paolo UNSPECIFIED UNSPECIFIED UNSPECIFIED Bertolino, Alessandro UNSPECIFIED UNSPECIFIED UNSPECIFIED Borgwardt, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Koutsouleris, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultze-Lutter, Frauke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-311231
DOI:	10.3389/fpsyt.2020.552175
Journal or Publication Title:	Front. Psychiatry
Volume:	11
Date:	2020
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-0640
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUPERIOR FRONTAL GYRUS; ULTRA-HIGH-RISK; GENERAL-POPULATION; SCHIZOPHRENIA; PREVALENCE; DISORDERS; ADOLESCENTS; BRAIN; PREVENTION; PREDICTION Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31123