Universität zu Köln

Hoffmann, Fabian ORCID: 0000-0002-3199-9924, Rabineau, Jeremy, Mehrkens, Dennis ORCID: 0000-0002-8578-0290, Gerlach, Darius A., Moestl, Stefan, Johannes, Bernd W., Caiani, Enrico G., Migeotte, Pierre Francois, Jordan, Jens and Tank, Jens . Cardiac adaptations to 60 day head-down-tilt bed rest deconditioning. Findings from the AGBRESA study. ESC Heart Fail.. SAN FRANCISCO: WILEY PERIODICALS, INC. ISSN 2055-5822

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Abstract

Aims Reduced physical activity increases the risk of heart failure; however, non-invasive methodologies detecting subclinical changes in myocardial function are not available. We hypothesized that myocardial, left ventricular, systolic strain measurements could capture subtle abnormalities in myocardial function secondary to physical inactivity. Methods and results In the AGBRESA study, which assessed artificial gravity through centrifugation as potential countermeasure for space travel, 24 healthy persons (eight women) were submitted to 60 day strict -6 degrees head-down-tilt bed rest. Participants were assigned to three groups of eight subjects: a control group, continuous artificial gravity training on a short-arm centrifuge (30 min/day), or intermittent centrifugation (6 x 5 min/day). We assessed cardiac morphology, function, strain, and haemodynamics by cardiac magnetic resonance imaging (MRI) and echocardiography. We observed no differences between groups and, therefore, conducted a pooled analysis. Consistent with deconditioning, resting heart rate (Delta 8.3 +/- 6.3 b. p.m., P < 0.0001), orthostatic heart rate responses (Delta 22.8 +/- 19.7 b.p.m., P < 0.0001), and diastolic blood pressure (Delta 8.8 +/- 6.6 mmHg, P < 0.0001) increased, whereas cardiac output (Delta-0.56 +/- 0.94 L/min, P = 0.0096) decreased during bed rest. Left ventricular mass index obtained by MRI did not change. Echocardiographic left ventricular, systolic, global longitudinal strain (Delta 1.8 +/- 1.83%, P < 0.0001) decreased, whereas left ventricular, systolic, global MRI circumferential strain increased not significantly (Delta-0.68 +/- 1.85%, P = 0.0843). MRI values rapidly returned to baseline during recovery. Conclusion Prolonged head-down-tilt bed rest provokes changes in cardiac function, particularly strain measurements, that appear functional rather than mediated through cardiac remodelling. Thus, strain measurements are of limited utility in assessing influences of physical deconditioning or exercise interventions on cardiac function.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoffmann, Fabian UNSPECIFIED orcid.org/0000-0002-3199-9924 UNSPECIFIED Rabineau, Jeremy UNSPECIFIED UNSPECIFIED UNSPECIFIED Mehrkens, Dennis UNSPECIFIED orcid.org/0000-0002-8578-0290 UNSPECIFIED Gerlach, Darius A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moestl, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Johannes, Bernd W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Caiani, Enrico G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Migeotte, Pierre Francois UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Tank, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-311393
DOI:	10.1002/ehf2.13103
Journal or Publication Title:	ESC Heart Fail.
Publisher:	WILEY PERIODICALS, INC
Place of Publication:	SAN FRANCISCO
ISSN:	2055-5822
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VENTRICULAR DIASTOLIC FUNCTION; DOSE-RESPONSE RELATIONSHIP; CENTRAL VENOUS-PRESSURE; PRELOAD DEPENDENCE; PHYSICAL-ACTIVITY; FAILURE; PERFORMANCE; WOMEN; RISK; MASS Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31139