Universität zu Köln

Huelsemann, Frank, Fusshoeller, Gregor, Lehn, Christine and Thevis, Mario (2020). Excretion of 19-norandrosterone after consumption of boar meat. Drug Test. Anal., 12 (11-12). S. 1581 - 1587. HOBOKEN: WILEY. ISSN 1942-7611

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Abstract

The consumption of the offal of noncastrated pigs can lead to the excretion of 19-norandrosterone (NorA) in urine of humans. In doping control, GC/C/IRMS is the method of choice to differentiate between an endogenous or exogenous origin of urinary NorA. In some cases, after the consumption of wild boar offal, the delta C-13 values of urinary NorA fulfill the criteria of an adverse analytical finding due to differing food sources of boar and consumer. However, consumption of wild boar's offal is not very common in Germany, and thus, the occurrence of such an analytical finding is unlikely. In contrast, the commerce with wild boar meat has increased in Germany within the last years. Up to 20,000 tons of wild boar meat are annually consumed. In order to probe for the probability of the occurrence of urinary NorA after consumption of wild boar meat, human urine samples were tested following the ingestion of commercially available game. In approximately half of the urine samples, traces of NorA were detected postadministration of 200 to 400 g boar meat. The highest urinary concentration was 2.9 ng/ml, and significant amounts were detected up to 9 h after the meal. delta C-13 values ranged from -18.5 parts per thousand to -23.5 parts per thousand, which would have led to at least two adverse analytical findings if the samples were collected in an antidoping context. IRMS analysis on German boar tissue samples showed that delta C-13 values for wild boar's steroids are unpredictable and may vary seasonally.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Huelsemann, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Fusshoeller, Gregor UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehn, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-311420
DOI:	10.1002/dta.2958
Journal or Publication Title:	Drug Test. Anal.
Volume:	12
Number:	11-12
Page Range:	S. 1581 - 1587
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1942-7611
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EDIBLE TISSUE CONSUMPTION; STABLE-ISOTOPE RATIOS; NANDROLONE METABOLITES; URINARY PROFILES; CARBON; 19-NORETIOCHOLANOLONE; QUANTIFICATION; IDENTIFICATION; CONSEQUENCE; NITROGEN Multiple languages Biochemical Research Methods; Chemistry, Analytical; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31142