Universität zu Köln

Binder, Ellen, Leimbach, Martha, Pool, Eva-Maria, Volz, Lukas J., Eickhoff, Simon B., Fink, Gereon R. and Grefkes, Christian ORCID: 0000-0002-1656-720X . Cortical reorganization after motor stroke: A pilot study on differences between the upper and lower limbs. Hum. Brain Mapp.. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

Stroke patients suffering from hemiparesis may show substantial recovery in the first months poststroke due to neural reorganization. While reorganization driving improvement of upper hand motor function has been frequently investigated, much less is known about the changes underlying recovery of lower limb function. We, therefore, investigated neural network dynamics giving rise to movements of both the hands and feet in 12 well-recovered left-hemispheric chronic stroke patients and 12 healthy participants using a functional magnetic resonance imaging sparse sampling design and dynamic causal modeling (DCM). We found that the level of neural activity underlying movements of the affected right hand and foot positively correlated with residual motor impairment, in both ipsilesional and contralesional premotor as well as left primary motor (M1) regions. Furthermore, M1 representations of the affected limb showed significantly stronger increase in BOLD activity compared to healthy controls and compared to the respective other limb. DCM revealed reduced endogenous connectivity of M1 of both limbs in patients compared to controls. However, when testing for the specific effect of movement on interregional connectivity, interhemispheric inhibition of the contralesional M1 during movements of the affected hand was not detected in patients whereas no differences in condition-dependent connectivity were found for foot movements compared to controls. In contrast, both groups featured positive interhemispheric M1 coupling, that is, facilitation of neural activity, mediating movements of the affected foot. These exploratory findings help to explain why functional recovery of the upper and lower limbs often develops differently after stroke, supporting limb-specific rehabilitative strategies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Binder, Ellen UNSPECIFIED UNSPECIFIED UNSPECIFIED Leimbach, Martha UNSPECIFIED UNSPECIFIED UNSPECIFIED Pool, Eva-Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Volz, Lukas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-311886
DOI:	10.1002/hbm.25275
Journal or Publication Title:	Hum. Brain Mapp.
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; EFFECTIVE CONNECTIVITY; NETWORK CONNECTIVITY; INTERHEMISPHERIC INTERACTIONS; CORTICOCORTICAL CONNECTIONS; ACTIVATION BALANCE; LOCOMOTOR RECOVERY; BRAIN ACTIVATION; NEURAL ACTIVITY; HAND MOVEMENTS Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31188