Universität zu Köln

Snelders, Nick C., Rovenich, Hanna, Petti, Gabriella C., Rocafort, Mercedes ORCID: 0000-0001-7192-695X, van den Berg, Grardy C. M., Vorholt, Julia A. ORCID: 0000-0002-6011-4910, Mesters, Jeroen R., Seidl, Michael F., Nijland, Reindert ORCID: 0000-0003-0049-3768 and Thomma, Bart P. H. J. ORCID: 0000-0003-4125-4181 (2020). Microbiome manipulation by a soil-borne fungal plant pathogen using effector proteins. Nat. Plants, 6 (11). S. 1365 - 1387. BERLIN: NATURE RESEARCH. ISSN 2055-0278

Full text not available from this repository.

Abstract

During colonization of their hosts, pathogens secrete effector proteins to promote disease development through various mechanisms. Increasing evidence shows that the host microbiome plays a crucial role in health, and that hosts actively shape their microbiomes to suppress disease. We proposed that pathogens evolved to manipulate host microbiomes to their advantage in turn. Here, we show that the previously identified virulence effector VdAve1, secreted by the fungal plant pathogen Verticillium dahliae, displays antimicrobial activity and facilitates colonization of tomato and cotton through the manipulation of their microbiomes by suppressing antagonistic bacteria. Moreover, we show that VdAve1, and also the newly identified antimicrobial effector VdAMP2, are exploited for microbiome manipulation in the soil environment, where the fungus resides in absence of a host. In conclusion, we demonstrate that a fungal plant pathogen uses effector proteins to modulate microbiome compositions inside and outside the host, and propose that pathogen effector catalogues represent an untapped resource for new antibiotics. A secreted protein effector from the fungal pathogen Verticillium dahliae has bactericidal properties. It allows the pathogen to modify the root microbiome in tomato and cotton, specifically eliminating plant-protective bacteria, to increase its own virulence.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Snelders, Nick C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rovenich, Hanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Petti, Gabriella C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rocafort, Mercedes UNSPECIFIED orcid.org/0000-0001-7192-695X UNSPECIFIED van den Berg, Grardy C. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vorholt, Julia A. UNSPECIFIED orcid.org/0000-0002-6011-4910 UNSPECIFIED Mesters, Jeroen R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seidl, Michael F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nijland, Reindert UNSPECIFIED orcid.org/0000-0003-0049-3768 UNSPECIFIED Thomma, Bart P. H. J. UNSPECIFIED orcid.org/0000-0003-4125-4181 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-312401
DOI:	10.1038/s41477-020-00799-5
Journal or Publication Title:	Nat. Plants
Volume:	6
Number:	11
Page Range:	S. 1365 - 1387
Date:	2020
Publisher:	NATURE RESEARCH
Place of Publication:	BERLIN
ISSN:	2055-0278
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Botanical Institute
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ARABIDOPSIS-THALIANA; VERTICILLIUM; RESISTANCE; DIVERSITY; VIRULENCE; PEPTIDES; GENOMES; DAHLIAE; LEAF Multiple languages Plant Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/31240