Universität zu Köln

Ries, C., Boese, C. K., Stuerznickel, J., Koehne, T., Hubert, J., Pastor, M. -F., Hahn, M., Meier, S. L., Beil, F. T., Pueschel, K., Amling, M. and Rolvien, T. (2020). Age-related changes of micro-morphological subchondral bone properties in the healthy femoral head. Osteoarthritis Cartilage, 28 (11). S. 1437 - 1448. OXFORD: ELSEVIER SCI LTD. ISSN 1522-9653

Full text not available from this repository.

Abstract

Objective: Alterations in the subchondral bone (SCB) are likely to play a decisive role in the development of osteoarthritis (OA). Since aging represents a major risk factor for OA, the aim of the current study was to assess the microstructural changes of the subchondral bone in the femoral head during aging. Design: Femoral heads and matched iliac crest biopsies of 80 individuals (age 21-99 years) were collected post-mortem. The bone microstructure of the subchondral trabecular bone as well as the cartilage thickness (Cg.Th) and subchondral bone plate thickness (SCB.Th) were quantified using histomorphometry. The different subregions of the SCB were also imaged by quantitative backscattered electron imaging (qBEI) in 31 aged cases to assess the bone mineral density distribution (BMDD). Results: The detected linear decline of bone volume per tissue volume (BV/TV) in the femoral head with aging (Slope, 95% CI: -0.208 to -0.109 %/yr.) was primarily due to a decrease in trabecular thickness (Tb.Th, Slope, 95% CI: -0.774 to -0.343 mm/yr). While SCB.Th declined with aging (Slope, 95% CI: -1.941 to -0.034 mm/yr), no changes in Cg.Th were detected (Slope, 95% CI: -0.001 to 0.005 mm/yr). The matrix mineralization of the subchondral bone was lower compared to the trabecular bone and also decreased with aging. Conclusions: Regular changes of the SCB during aging primarily involve a reduction of Tb.Th, SCB.Th and matrix mineralization. Our findings facilitate future interpretations of early and late OA specimens to decipher the role of the SCB in OA pathogenesis. (C) 2020 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ries, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boese, C. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stuerznickel, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koehne, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hubert, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pastor, M. -F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hahn, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meier, S. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beil, F. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pueschel, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Amling, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rolvien, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-313841
DOI:	10.1016/j.joca.2020.08.001
Journal or Publication Title:	Osteoarthritis Cartilage
Volume:	28
Number:	11
Page Range:	S. 1437 - 1448
Date:	2020
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1522-9653
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DENSITY DISTRIBUTION; ARTICULAR-CARTILAGE; KNEE-JOINT; OSTEOARTHRITIS; MINERALIZATION; RESORPTION; TISSUE; MICROARCHITECTURE Multiple languages Orthopedics; Rheumatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31384