Universität zu Köln

Behfar, Qumars, Behfar, Stefan Kambiz, von Reutern, Boris, Richter, Nils, Dronse, Julian, Fassbender, Ronja, Fink, Gereon R. and Onur, Oezguer A. (2020). Graph Theory Analysis Reveals Resting-State Compensatory Mechanisms in Healthy Aging and Prodromal Alzheimer's Disease. Front. Aging Neurosci., 12. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1663-4365

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Abstract

Several theories of cognitive compensation have been suggested to explain sustained cognitive abilities in healthy brain aging and early neurodegenerative processes. The growing number of studies investigating various aspects of task-based compensation in these conditions is contrasted by the shortage of data about resting-state compensatory mechanisms. Using our proposed criterion-based framework for compensation, we investigated 45 participants in three groups: (i) patients with mild cognitive impairment (MCI) and positive biomarkers indicative of Alzheimer's disease (AD); (ii) cognitively normal young adults; (iii) cognitively normal older adults. To increase reliability, three sessions of resting-state functional magnetic resonance imaging for each participant were performed on different days (135 scans in total). To elucidate the dimensions and dynamics of resting-state compensatory mechanisms, we used graph theory analysis along with volumetric analysis. Graph theory analysis was applied based on the Brainnetome atlas, which provides a connectivity-based parcellation framework. Comprehensive neuropsychological examinations including the Rey Auditory Verbal Learning Test (RAVLT) and the Trail Making Test (TMT) were performed, to relate graph measures of compensatory nodes to cognition. To avoid false-positive findings, results were corrected for multiple comparisons. First, we observed an increase of degree centrality in cognition related brain regions of the middle frontal gyrus, precentral gyrus and superior parietal lobe despite local atrophy in MCI and healthy aging, indicating a resting-state connectivity increase with positive biomarkers. When relating the degree centrality measures to cognitive performance, we observed that greater connectivity led to better RAVLT and TMT scores in MCI and, hence, might constitute a compensatory mechanism. The detection and improved understanding of the compensatory dynamics in healthy aging and prodromal AD is mandatory for implementing and tailoring preventive interventions aiming at preserved overall cognitive functioning and delayed clinical onset of dementia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Behfar, Qumars UNSPECIFIED UNSPECIFIED UNSPECIFIED Behfar, Stefan Kambiz UNSPECIFIED UNSPECIFIED UNSPECIFIED von Reutern, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Richter, Nils UNSPECIFIED UNSPECIFIED UNSPECIFIED Dronse, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Fassbender, Ronja UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Onur, Oezguer A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-314458
DOI:	10.3389/fnagi.2020.576627
Journal or Publication Title:	Front. Aging Neurosci.
Volume:	12
Date:	2020
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1663-4365
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; VERBAL WORKING-MEMORY; CONNECTIVITY; MAINTENANCE; NETWORKS; DYNAMICS; ACTIVATIONS; DEFINITION; REDUCTION; FRAMEWORK Multiple languages Geriatrics & Gerontology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31445