Universität zu Köln

Christopeit, Maximilian ORCID: 0000-0003-4627-0412, Schmidt-Hieber, Martin, Sprute, Rosanne ORCID: 0000-0003-2457-6437, Buchheidt, Dieter, Hentrich, Marcus, Karthaus, Meinolf, Penack, Olaf, Ruhnke, Markus, Weissinger, Florian, Cornely, Oliver A. and Maschmeyer, Georg . Prophylaxis, diagnosis and therapy of infections in patients undergoing high-dose chemotherapy and autologous haematopoietic stem cell transplantation. 2020 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO). Ann. Hematol.. NEW YORK: SPRINGER. ISSN 1432-0584

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Abstract

To ensure the safety of high-dose chemotherapy and autologous stem cell transplantation (HDC/ASCT), evidence-based recommendations on infectious complications after HDC/ASCT are given. This guideline not only focuses on patients with haematological malignancies but also addresses the specifics of HDC/ASCT patients with solid tumours or autoimmune disorders. In addition to HBV and HCV, HEV screening is nowadays mandatory prior to ASCT. For patients with HBs antigen and/or anti-HBc antibody positivity, HBV nucleic acid testing is strongly recommended for 6 months after HDC/ASCT or for the duration of a respective maintenance therapy. Prevention of VZV reactivation by vaccination is strongly recommended. Cotrimoxazole for the prevention ofPneumocystis jiroveciiis supported. Invasive fungal diseases are less frequent after HDC/ASCT, therefore, primary systemic antifungal prophylaxis is not recommended. Data do not support a benefit of protective room ventilation e.g. HEPA filtration. Thus, AGIHO only supports this technique with marginal strength. Fluoroquinolone prophylaxis is recommended to prevent bacterial infections, although a survival advantage has not been demonstrated.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Christopeit, Maximilian UNSPECIFIED orcid.org/0000-0003-4627-0412 UNSPECIFIED Schmidt-Hieber, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Sprute, Rosanne UNSPECIFIED orcid.org/0000-0003-2457-6437 UNSPECIFIED Buchheidt, Dieter UNSPECIFIED UNSPECIFIED UNSPECIFIED Hentrich, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED Karthaus, Meinolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Penack, Olaf UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhnke, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Weissinger, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maschmeyer, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-314586
DOI:	10.1007/s00277-020-04297-8
Journal or Publication Title:	Ann. Hematol.
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-0584
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BLOOD-STREAM INFECTION; FEBRILE NEUTROPENIC PATIENTS; INVASIVE FUNGAL-INFECTIONS; PREEMPTIVE ANTIFUNGAL THERAPY; LIPOSOMAL AMPHOTERICIN-B; PLACEBO-CONTROLLED TRIAL; HIGH-RISK; HERPES-ZOSTER; PIPERACILLIN-TAZOBACTAM; ANTIMICROBIAL THERAPY Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31458