Universität zu Köln

Sannemann, Lena, Schild, Ann-Katrin, Altenstein, Slawek, Bartels, Claudia, Brosseron, Frederic, Buerger, Katharina, Cosma, Nicoleta Carmen, Fliessbach, Klaus, Freiesleben, Silka Dawn, Glanz, Wenzel, Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Kobeleva, Xenia, Laske, Christoph, Metzger, Coraline D., Munk, Matthias H. J., Perneczky, Robert, Peters, Oliver, Polcher, Alexandra, Priller, Josef, Rauchmann, Boris, Roesch, Christina, Rudolph, Janna, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan, Vukovich, Ruth, Wagner, Michael ORCID: 0000-0003-2589-6440, Wiltfang, Jens, Wolfsgruber, Steffen, Duezel, Emrah and Jessen, Frank (2020). Neuropsychiatric symptoms in at-risk groups for AD dementia and their association with worry and AD biomarkers-results from the DELCODE study. Alzheimers Res. Ther., 12 (1). LONDON: BMC. ISSN 1758-9193

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Abstract

BackgroundEarly identification of individuals at risk of dementia is mandatory to implement prevention strategies and design clinical trials that target early disease stages. Subjective cognitive decline (SCD) and neuropsychiatric symptoms (NPS) have been proposed as potential markers for early manifestation of Alzheimer's disease (AD). We aimed to investigate the frequency of NPS in SCD, in other at-risk groups, in healthy controls (CO), and in AD patients, and to test the association of NPS with AD biomarkers, with a particular focus on cognitively unimpaired participants with or without SCD-related worries.MethodsWe analyzed data of n=687 participants from the German DZNE Longitudinal Cognitive Impairment and Dementia (DELCODE) study, including the diagnostic groups SCD (n=242), mild cognitive impairment (MCI, n=115), AD (n=77), CO (n=209), and first-degree relatives of AD patients (REL, n=44). The Neuropsychiatric Inventory Questionnaire (NPI-Q), Geriatric Depression Scale (GDS-15), and Geriatric Anxiety Inventory (GAI-SF) were used to assess NPS. We examined differences of NPS frequency between diagnostic groups. Logistic regression analyses were carried out to further investigate the relationship between NPS and cerebrospinal fluid (CSF) AD biomarkers, focusing on a subsample of cognitively unimpaired participants (SCD, REL, and CO), who were further differentiated based on reported worries.ResultsThe numbers of reported NPS, depression scores, and anxiety scores were significantly higher in subjects with SCD compared to CO. The quantity of reported NPS in subjects with SCD was lower compared to the MCI and AD group. In cognitively unimpaired subjects with worries, low A ss 42 was associated with higher rates of reporting two or more NPS (OR 0.998, 95% CI 0.996-1.000, p<.05).ConclusionThese findings give insight into the prevalence of NPS in different diagnostic groups, including SCD and healthy controls. NPS based on informant report seem to be associated with underlying AD pathology in cognitively unimpaired participants who worry about cognitive decline.Trial registrationGerman Clinical Trials Register DRKS00007966. Registered 4 May 2015.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sannemann, Lena UNSPECIFIED UNSPECIFIED UNSPECIFIED Schild, Ann-Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Altenstein, Slawek UNSPECIFIED UNSPECIFIED UNSPECIFIED Bartels, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Brosseron, Frederic UNSPECIFIED UNSPECIFIED UNSPECIFIED Buerger, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Cosma, Nicoleta Carmen UNSPECIFIED UNSPECIFIED UNSPECIFIED Fliessbach, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Freiesleben, Silka Dawn UNSPECIFIED UNSPECIFIED UNSPECIFIED Glanz, Wenzel UNSPECIFIED UNSPECIFIED UNSPECIFIED Heneka, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Janowitz, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Kilimann, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Kobeleva, Xenia UNSPECIFIED UNSPECIFIED UNSPECIFIED Laske, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Metzger, Coraline D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Munk, Matthias H. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Perneczky, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Polcher, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Priller, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Rauchmann, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Roesch, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Rudolph, Janna UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Spottke, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Spruth, Eike Jakob UNSPECIFIED UNSPECIFIED UNSPECIFIED Teipel, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Vukovich, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Wiltfang, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolfsgruber, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Duezel, Emrah UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-314757
DOI:	10.1186/s13195-020-00701-7
Journal or Publication Title:	Alzheimers Res. Ther.
Volume:	12
Number:	1
Date:	2020
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1758-9193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; BEHAVIORAL IMPAIRMENT; CLINICAL PROGRESSION; MEMORY COMPLAINTS; OLDER-PEOPLE; DECLINE; MANIFESTATIONS; POPULATION; VALIDATION Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31475