Universität zu Köln

Csordas, Gabor ORCID: 0000-0001-6871-6839, Grawe, Ferdinand and Uhlirova, Mirka ORCID: 0000-0002-5735-8287 (2020). Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments. eLife, 9. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

Blood development in multicellular organisms relies on specific tissue microenvironments that nurture hematopoietic precursors and promote their self-renewal, proliferation, and differentiation. The mechanisms driving blood cell homing and their interactions with hematopoietic microenvironments remain poorly understood. Here, we use the Drosophila melanogaster model to reveal a pivotal role for basement membrane composition in the formation of hematopoietic compartments. We demonstrate that by modulating extracellular matrix components, the fly blood cells known as hemocytes can be relocated to tissue surfaces where they function similarly to their natural hematopoietic environment. We establish that the Collagen XV/XVIII ortholog Multiplexin in the tissue-basement membranes and the phagocytosis receptor Eater on the hemocytes physically interact and are necessary and sufficient to induce immune cell-tissue association. These results highlight the cooperation of Multiplexin and Eater as an integral part of a homing mechanism that specifies and maintains hematopoietic sites in Drosophila

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Csordas, Gabor UNSPECIFIED orcid.org/0000-0001-6871-6839 UNSPECIFIED Grawe, Ferdinand UNSPECIFIED UNSPECIFIED UNSPECIFIED Uhlirova, Mirka UNSPECIFIED orcid.org/0000-0002-5735-8287 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-315514
DOI:	10.7554/eLife.57297
Journal or Publication Title:	eLife
Volume:	9
Date:	2020
Publisher:	ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELLULAR IMMUNE-RESPONSE; DROSOPHILA-LYMPH GLAND; STEM-CELL; TRANSMEMBRANE PROTEIN; EXTRACELLULAR-MATRIX; INCREASED EXPRESSION; HEMOCYTE LINEAGES; COLLAGEN XVIII; ATF3; RECEPTOR Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/31551