Universität zu Köln

Wagner, Ben, Clos, Mareike, Sommer, Tobias ORCID: 0000-0002-3504-7357 and Peters, Jan ORCID: 0000-0002-0195-5357 (2020). Dopaminergic Modulation of Human Intertemporal Choice: A Diffusion Model Analysis Using the D2-Receptor Antagonist Haloperidol. J. Neurosci., 40 (41). S. 7936 - 7949. WASHINGTON: SOC NEUROSCIENCE. ISSN 1529-2401

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Abstract

The neurotransmitter dopamine is implicated in diverse functions, including reward processing, reinforcement learning, and cognitive control. The tendency to discount future rewards over time has long been discussed in the context of potential do-paminergic modulation. Here we examined the effect of a single dose of the D2 receptor antagonist haloperidol (2 mg) on temporal discounting in healthy female and male human participants. Our approach extends previous pharmacological studies in two ways. First, we applied combined temporal discounting drift diffusion models to examine choice dynamics. Second, we examined dopaminergic modulation of reward magnitude effects on temporal discounting. Hierarchical Bayesian parameter estimation revealed that the data were best accounted for by a temporal discounting drift diffusion model with nonlinear trialwise drift rate scaling. This model showed good parameter recovery, and posterior predictive checks revealed that it accurately reproduced the relationship between decision conflict and response times in individual participants. We observed reduced temporal discounting and substantially faster nondecision times under haloperidol compared with placebo. Discounting was steeper for low versus high reward magnitudes, but this effect was largely unaffected by haloperidol. Results were corroborated by model-free analyses and modeling via more standard approaches. We previously reported elevated caudate activation under haloperidol in this sample of participants, supporting the idea that haloperidol elevated dopamine neurotransmission (e.g., by blocking inhibitory feedback via presynaptic D2 auto-receptors). The present results reveal that this is associated with an augmentation of both lower-level (nondecision time) and higher-level (temporal discounting) components of the decision process.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wagner, Ben UNSPECIFIED UNSPECIFIED UNSPECIFIED Clos, Mareike UNSPECIFIED UNSPECIFIED UNSPECIFIED Sommer, Tobias UNSPECIFIED orcid.org/0000-0002-3504-7357 UNSPECIFIED Peters, Jan UNSPECIFIED orcid.org/0000-0002-0195-5357 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-315536
DOI:	10.1523/JNEUROSCI.0592
Journal or Publication Title:	J. Neurosci.
Volume:	40
Number:	41
Page Range:	S. 7936 - 7949
Date:	2020
Publisher:	SOC NEUROSCIENCE
Place of Publication:	WASHINGTON
ISSN:	1529-2401
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DECISION-MAKING; SELF-CONTROL; PREFRONTAL CORTEX; D-AMPHETAMINE; REWARD; IMPULSIVITY; TIME; MECHANISMS; DECREASES; COGNITION Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31553