Haas, Shalaila S., Antonucci, Linda A., Wenzel, Julian, Ruef, Anne, Biagianti, Bruno, Paolini, Marco, Rauchmann, Boris-Stephan, Weiske, Johanna, Kambeitz, Joseph, Borgwardt, Stefan ORCID: 0000-0002-5792-3987, Brambilla, Paolo, Meisenzahl, Eva, Salokangas, Raimo K. R., Upthegrove, Rachel ORCID: 0000-0001-8204-5103, Wood, Stephen J., Koutsouleris, Nikolaos and Kambeitz-Ilankovic, Lana . A multivariate neuromonitoring approach to neuroplasticity-based computerized cognitive training in recent onset psychosis. Neuropsychopharmacology. LONDON: SPRINGERNATURE. ISSN 1740-634X

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Abstract

Two decades of studies suggest that computerized cognitive training (CCT) has an effect on cognitive improvement and the restoration of brain activity. Nevertheless, individual response to CCT remains heterogenous, and the predictive potential of neuroimaging in gauging response to CCT remains unknown. We employed multivariate pattern analysis (MVPA) on whole-brain resting-state functional connectivity (rsFC) to (neuro)monitor clinical outcome defined as psychosis-likeness change after 10-hours of CCT in recent onset psychosis (ROP) patients. Additionally, we investigated if sensory processing (SP) change during CCT is associated with individual psychosis-likeness change and cognitive gains after CCT. 26 ROP patients were divided into maintainers and improvers based on their SP change during CCT. A support vector machine (SVM) classifier separating 56 healthy controls (HC) from 35 ROP patients using rsFC (balanced accuracy of 65.5%,P < 0.01) was built in an independent sample to create a naturalistic model representing the HC-ROP hyperplane. This model was out-of-sample cross-validated in the ROP patients from the CCT trial to assess associations between rsFC pattern change, cognitive gains and SP during CCT. Patients with intact SP threshold at baseline showed improved attention despite psychosis status on the SVM hyperplane at follow-up (p < 0.05). Contrarily, the attentional gains occurred in the ROP patients who showed impaired SP at baseline only if rsfMRI diagnosis status shifted to the healthy-like side of the SVM continuum. Our results reveal the utility of MVPA for elucidating treatment response neuromarkers based on rsFC-SP change and pave the road to more personalized interventions.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Haas, Shalaila S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonucci, Linda A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wenzel, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruef, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biagianti, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paolini, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rauchmann, Boris-StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weiske, JohannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgwardt, StefanUNSPECIFIEDorcid.org/0000-0002-5792-3987UNSPECIFIED
Brambilla, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meisenzahl, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salokangas, Raimo K. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Upthegrove, RachelUNSPECIFIEDorcid.org/0000-0001-8204-5103UNSPECIFIED
Wood, Stephen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koutsouleris, NikolaosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz-Ilankovic, LanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-315550
DOI: 10.1038/s41386-020-00877-4
Journal or Publication Title: Neuropsychopharmacology
Publisher: SPRINGERNATURE
Place of Publication: LONDON
ISSN: 1740-634X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STATE FUNCTIONAL CONNECTIVITY; 1ST-EPISODE SCHIZOPHRENIA; NEUROIMAGING BIOMARKERS; IMAGING BIOMARKERS; TREATMENT RESPONSE; CHILDHOOD TRAUMA; MOTION ARTIFACT; REMEDIATION; PREDICTION; METAANALYSISMultiple languages
Neurosciences; Pharmacology & Pharmacy; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31555

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