Universität zu Köln

Kim, Christine S., Ding, Xiaolei, Allmeroth, Kira, Biggs, Leah C., Kolenc, Olivia, I, L'Hoest, Nina, Chacon-Martinez, Carlos Andres, Edlich-Muth, Christian, Giavalisco, Patrick, Quinn, Kyle P., Denzel, Martin S., Eming, Sabine A. and Wickstrom, Sara A. (2020). Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle. Cell Metab., 32 (4). S. 629 - 651. CAMBRIDGE: CELL PRESS. ISSN 1932-7420

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Abstract

Stem cells reside in specialized niches that are critical for their function. Upon activation, hair follicle stem cells (HFSCs) exit their niche to generate the outer root sheath (ORS), but a subset of ORS progeny returns to the niche to resume an SC state. Mechanisms of this fate reversibility are unclear. We show that the ability of ORS cells to return to the SC state requires suppression of a metabolic switch from glycolysis to oxidative phosphorylation and glutamine metabolism that occurs during early HFSC lineage progression. HFSC fate reversibility and glutamine metabolism are regulated by the mammalian target of rapamycin complex 2 (mTORC2)-Akt signaling axis within the niche. Deletion of mTORC2 results in a failure to re-establish the HFSC niche, defective hair follicle regeneration, and compromised long-term maintenance of HFSCs. These findings highlight the importance of spatiotemporal control of SC metabolic states in organ homeostasis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kim, Christine S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ding, Xiaolei UNSPECIFIED UNSPECIFIED UNSPECIFIED Allmeroth, Kira UNSPECIFIED UNSPECIFIED UNSPECIFIED Biggs, Leah C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kolenc, Olivia, I UNSPECIFIED UNSPECIFIED UNSPECIFIED L'Hoest, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Chacon-Martinez, Carlos Andres UNSPECIFIED UNSPECIFIED UNSPECIFIED Edlich-Muth, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Giavalisco, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Quinn, Kyle P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Denzel, Martin S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eming, Sabine A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wickstrom, Sara A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-315608
DOI:	10.1016/j.cmet.2020.08.011
Journal or Publication Title:	Cell Metab.
Volume:	32
Number:	4
Page Range:	S. 629 - 651
Date:	2020
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1932-7420
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MASS-SPECTROMETRY; SKIN; INHIBITION; GROWTH; HIF-1-ALPHA; TRANSPORT; CANCER; RICTOR; NICHE; CHAIN Multiple languages Cell Biology; Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31560