Universität zu Köln

Meyer, Kristian, Leweke, Samuel ORCID: 0000-0001-9471-4511, von Lieres, Eric, Huusom, Jakob K. and Abildskov, Jens ORCID: 0000-0003-1187-8778 (2020). ChromaTech: A discontinuous Galerkin spectral element simulator for preparative liquid chromatography. Comput. Chem. Eng., 141. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-4375

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Abstract

ChromaTech is a simulator for preparative liquid chromatography processes with mass transport de-scribed by the pore and surface diffusion general rate model. A discontinuous Galerkin spectral element method is used for spatial discretization with exponential decay of approximation errors within elements. The code is validated by numerically reproducing a high-precision reference obtained with CADET-semi -analytic. The performance of ChromaTech is tested by comparing against CADET, a dedicated code based on a weighted essentially non-oscillatory finite volume method with second (low) order spatial accuracy. Reassuringly, ChromaTech provides exactly the same chromatograms as CADET for multicomponent pro-tein purification cases with linear and non-linear adsorption dynamics. However, the numerical results show, that ChromaTech has superior efficiency in terms of computational cost and discrete problem size without compromising stability. The spatial discretization is the major difference between the two codes for solution of the pore and surface diffusion general rate model. Thus, it demonstrates, that spectral methods are not just competitive with second (low) order accurate methods often used by default, but simply a superior approach for spatial discretization of liquid chromatography flow problems in terms of computational efficiency. (c) 2020 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Meyer, Kristian UNSPECIFIED UNSPECIFIED UNSPECIFIED Leweke, Samuel UNSPECIFIED orcid.org/0000-0001-9471-4511 UNSPECIFIED von Lieres, Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED Huusom, Jakob K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Abildskov, Jens UNSPECIFIED orcid.org/0000-0003-1187-8778 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-315788
DOI:	10.1016/j.compchemeng.2020.107012
Journal or Publication Title:	Comput. Chem. Eng.
Volume:	141
Date:	2020
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-4375
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENERAL RATE MODEL; PREDICTIVE CONTROL; ADSORPTION; DESIGN; DIFFUSION; PROTEIN; PHENOL; BATCH Multiple languages Computer Science, Interdisciplinary Applications; Engineering, Chemical Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31578