Universität zu Köln

Steven, Philipp ORCID: 0000-0001-6892-3619, Schwab, Sebastian, Kiesewetter, Anne, Saban, Daniel R., Stern, Michael E. and Gehlsen, Uta ORCID: 0000-0001-9057-9199 (2020). Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy. Int. J. Mol. Sci., 21 (20). BASEL: MDPI. ISSN 1422-0067

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Abstract

Conjunctiva-associated tissue (CALT) is assumed to play a crucial role in the immune system of the ocular surface. Its function in several ocular surface diseases (OSD) is still not fully understood. This study investigates the function of CALT in mouse models of dry-eye disease and ocular allergy. Since antigen-presentation is the central similarity in the pathologies, this study focuses on antigen-presentation in CALT Morphology and the expression of CALT, which was investigated in mice after induction of dry-eye, ocular allergy, topical antigen-stimulation, and after local depletion of phagocytic cells. Antigen uptake was investigated after the application of fluorescent ovalbumin (OVA). OSD influences the appearance and morphology of CALT in a disease-dependent manner. Ocular allergy leads to an increase and dry-eye disease to a decrease in number and size of CALT. The development of CALT is dependent on the presence of APCs. Professional APCs are present in CALT, and soluble antigen is transported into the follicle. CALT appearance is disease-specific and indicative of differing functions. Although the specific involvement of CALT in OSD needs further study, the existence of functional APCS and antigen-uptake supports the hypothesis that CALT is an immunological key player at the ocular surface.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Steven, Philipp UNSPECIFIED orcid.org/0000-0001-6892-3619 UNSPECIFIED Schwab, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kiesewetter, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Saban, Daniel R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stern, Michael E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gehlsen, Uta UNSPECIFIED orcid.org/0000-0001-9057-9199 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-316467
DOI:	10.3390/ijms21207514
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	21
Number:	20
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTESTINAL EPITHELIAL-CELLS; ANTIGEN-PRESENTING CELLS; DENDRITIC CELLS; MACROPHAGES; SURFACE; MUCOSA; AUTOANTIBODIES; IDENTIFICATION; IMMUNE Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31646