Universität zu Köln

Frisoni, Giovanni B., Luis Molinuevo, Jose, Altomare, Daniele ORCID: 0000-0003-1905-8993, Carrera, Emmanuel ORCID: 0000-0003-0045-5382, Barkhof, Frederik ORCID: 0000-0003-3543-3706, Berkhof, Johannes, Delrieu, Julien, Dubois, Bruno, Kivipelto, Miia, Nordberg, Agneta, Schott, Jonathan M., van der Flier, Wiesje M., Vellas, Bruno, Jessen, Frank, Scheltens, Philip and Ritchie, Craig (2020). Precision prevention of Alzheimer's and other dementias: Anticipating future needs in the control of risk factors and implementation of disease-modifying therapies. Alzheimers. Dement., 16 (10). S. 1457 - 1469. HOBOKEN: WILEY. ISSN 1552-5279

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Abstract

Empirical evidence suggests that a fair proportion of dementia cases are preventable, that some preventive actions can be taken immediately, and others may soon be implemented. Primary prevention may target cognitively normal persons with modifiable risk factors through lifestyle and multiple domain interventions (including general cardiovascular health). While the effect on individuals may be modest, it might have a large societal impact by decreasing overall dementia incidence by Secondary prevention will target cognitively normal persons at high risk of dementia due to Alzheimer's disease pathology with future anti-amyloid, anti-tau, or other drugs. This approach is likely to have major benefits to both individuals and society. Memory clinics will need structural and functional changes to adapt to novel technologies and increased patients' demands, and brand-new services may need to be developed with specific skills on risk profiling, risk communication, and personalized risk reduction plans.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Frisoni, Giovanni B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Luis Molinuevo, Jose UNSPECIFIED UNSPECIFIED UNSPECIFIED Altomare, Daniele UNSPECIFIED orcid.org/0000-0003-1905-8993 UNSPECIFIED Carrera, Emmanuel UNSPECIFIED orcid.org/0000-0003-0045-5382 UNSPECIFIED Barkhof, Frederik UNSPECIFIED orcid.org/0000-0003-3543-3706 UNSPECIFIED Berkhof, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Delrieu, Julien UNSPECIFIED UNSPECIFIED UNSPECIFIED Dubois, Bruno UNSPECIFIED UNSPECIFIED UNSPECIFIED Kivipelto, Miia UNSPECIFIED UNSPECIFIED UNSPECIFIED Nordberg, Agneta UNSPECIFIED UNSPECIFIED UNSPECIFIED Schott, Jonathan M. UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Flier, Wiesje M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vellas, Bruno UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheltens, Philip UNSPECIFIED UNSPECIFIED UNSPECIFIED Ritchie, Craig UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-316801
DOI:	10.1002/alz.12132
Journal or Publication Title:	Alzheimers. Dement.
Volume:	16
Number:	10
Page Range:	S. 1457 - 1469
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1552-5279
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COGNITIVE FUNCTION; TRENDS; CARE; INTERVENTION; DEFINITION; IMPAIRMENT; STATEMENT; HEALTH; ADULTS Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31680