Universität zu Köln

Limper, Ulrich, Fiala, Vera, Tank, Jens, Elmenhorst, Eva-Maria, Schaelte, Gereon, Hew, Ya-Yu Monica, Gauger, Peter, Martus, Peter ORCID: 0000-0002-5386-5732 and Jordan, Jens (2020). Sleeping with Elevated Upper Body Does Not Attenuate Acute Mountain Sickness: Pragmatic Randomized Clinical Trial. Am. J. Med., 133 (10). S. E584 - 5. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1555-7162

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Abstract

PURPOSE: Acute mountain sickness commonly occurs following ascent to high altitude and is aggravated following sleep. Cephalad fluid shifts have been implicated. We hypothesized that sleeping with the upper body elevated by 30 degrees reduces the risk of acute mountain sickness. METHODS: In a pragmatic, randomized, observer-blinded field study at 4554 meters altitude, we investigated 134 adults aged 18-70 years with a Lake Louise score between 3 and 12 points on the evening of their arrival at the altitude. The individuals were exposed to sleeping on an inflatable cushion elevating the upper body by 30 degrees or on a sham pillow in a horizontal position. The primary endpoint was the change in the Acute Mountain Sickness-Cerebral (AMS-C) score in the morning after sleeping at an altitude of 4554 meters compared with the evening before. Sleep efficiency was the secondary endpoint. RESULTS: Among 219 eligible mountaineers, 134 fulfilled the inclusion criteria and were randomized. The AMS-C score increased by 0.250 +/- 0.575 in the control group and by 0.121 +/- 0.679 in the intervention group (difference 0.105; 95% confidence interval, -0.098-0.308; P = .308). Oxygen saturation in the morning was 79% +/- 6% in the intervention group and 78% +/- 6% in the control group (P = .863). Sleep efficiency did not differ between groups (P = .115). CONCLUSIONS: Sleeping with the upper body elevated by 30 degrees does not lead to relevant reductions in acute mountain sickness symptoms or hypoxemia at high altitude. (C) 2020 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Limper, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Fiala, Vera UNSPECIFIED UNSPECIFIED UNSPECIFIED Tank, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Elmenhorst, Eva-Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaelte, Gereon UNSPECIFIED UNSPECIFIED UNSPECIFIED Hew, Ya-Yu Monica UNSPECIFIED UNSPECIFIED UNSPECIFIED Gauger, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Martus, Peter UNSPECIFIED orcid.org/0000-0002-5386-5732 UNSPECIFIED Jordan, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-316823
DOI:	10.1016/j.amjmed.2020.01.024
Journal or Publication Title:	Am. J. Med.
Volume:	133
Number:	10
Page Range:	S. E584 - 5
Date:	2020
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1555-7162
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31682