Universität zu Köln

Grimmer, Timo, Shi, Kuangyu, Diehl-Schmid, Janine ORCID: 0000-0002-7745-1382, Natale, Bianca, Drzezga, Alexander, Foerster, Stefan, Foerstl, Hans, Schwaiger, Markus, Yakushev, Igor, Wester, Hans-Juergen, Kurz, Alexander and Yousefi, Behrooz Hooshyar (2020). F-18-FIBT may expand PET for beta-amyloid imaging in neurodegenerative diseases. Mol. Psychiatr., 25 (10). S. 2608 - 2620. LONDON: SPRINGERNATURE. ISSN 1476-5578

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Abstract

F-18-FIBT, 2-(p-Methylaminophenyl)-7-(2-[F-18]fluoroethoxy)imidazo-[2,1-b]benzothiazole, is a new selective PET tracer under clinical investigation to specifically image beta-amyloid depositions (A beta) in humans in-vivo that binds to A beta with excellent affinity (K(d)0.7 +/- 0.2) and high selectivity over tau and alpha-synuclein aggregates (Ki > 1000 nM). We aimed to characterize(18)F-FIBT in a series of patients with different clinical-pathophysiological phenotypes and to compare its binding characteristics to the reference compound PiB. Six patients (mild late-onset and moderate early-onset AD dementia, mild cognitive impairment due to AD, intermediate likelihood, mild behavioral variant of frontotemporal dementia, subjective memory impairment without evidence of neurodegeneration, and mild dementia due to Posterior Cortical Atrophy) underwent PET imaging with(18)F-FIBT on PET/MR. With the guidance of MRI, PET images were corrected for partial volume effect, time-activity curves (TACs) of regions of interest (ROIs) were extracted, and non-displaceable binding potentials (BPnd), standardized uptake value ratios (SUVR), and distribution volume ratio (DVR) were compared. Specific binding was detected in the cases with evidence of the AD pathophysiological process visualized in images of BPnd, DVR and SUVR, consistently with patterns of different tracers in previous studies. SUVR showed the highest correlation with clinical severity. The previous preclinical characterization and the results of this case series suggest the clinical usefulness of FIBT as a selective and highly affine next-generation(18)F-labeled tracer for amyloid-imaging with excellent pharmacokinetics in the diagnosis of neurodegenerative diseases. The results compare well to the gold standard PiB and hence support further investigation in larger human samples.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grimmer, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Shi, Kuangyu UNSPECIFIED UNSPECIFIED UNSPECIFIED Diehl-Schmid, Janine UNSPECIFIED orcid.org/0000-0002-7745-1382 UNSPECIFIED Natale, Bianca UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Foerster, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Foerstl, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwaiger, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Yakushev, Igor UNSPECIFIED UNSPECIFIED UNSPECIFIED Wester, Hans-Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurz, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Yousefi, Behrooz Hooshyar UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-317682
DOI:	10.1038/s41380-018-0203-5
Journal or Publication Title:	Mol. Psychiatr.
Volume:	25
Number:	10
Page Range:	S. 2608 - 2620
Date:	2020
Publisher:	SPRINGERNATURE
Place of Publication:	LONDON
ISSN:	1476-5578
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REFERENCE TISSUE MODEL; POSITRON-EMISSION-TOMOGRAPHY; WHITE-MATTER REFERENCE; ALZHEIMERS-DISEASE; GRAPHICAL ANALYSIS; BINDING; QUANTIFICATION; DEMENTIA; IMPACT; PREVALENCE Multiple languages Biochemistry & Molecular Biology; Neurosciences; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31768