Universität zu Köln

Stefanou, Maria Elena ORCID: 0000-0001-6469-2876, Dundon, Neil M., Bestelmeyer, Patricia E. G., Ioannou, Chara, Bender, Stephan, Biscaldi, Monica, Smyrnis, Nikolaos and Klein, Christoph (2020). Late attentional processes potentially compensate for early perceptual multisensory integration deficits in children with autism: evidence from evoked potentials. Sci Rep, 10 (1). BERLIN: NATURE RESEARCH. ISSN 2045-2322

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Abstract

Sensory processing deficits and altered long-range connectivity putatively underlie Multisensory Integration (MSI) deficits in Autism Spectrum Disorder (ASD). The present study set out to investigate non-social MSI stimuli and their electrophysiological correlates in young neurotypical adolescents and adolescents with ASD. We report robust MSI effects at behavioural and electrophysiological levels. Both groups demonstrated normal behavioural MSI. However, at the neurophysiological level, the ASD group showed less MSI-related reduction of the visual P100 latency, greater MSI-related slowing of the auditory P200 and an overall temporally delayed and spatially constrained onset of MSI. Given the task design and patient sample, and the age of our participants, we argue that electro-cortical indices of MSI deficits in ASD: (a) can be detected in early-adolescent ASD, (b) occur at early stages of perceptual processing, (c) can possibly be compensated by later attentional processes, (d) thus leading to normal MSI at the behavioural level.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stefanou, Maria Elena UNSPECIFIED orcid.org/0000-0001-6469-2876 UNSPECIFIED Dundon, Neil M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bestelmeyer, Patricia E. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ioannou, Chara UNSPECIFIED UNSPECIFIED UNSPECIFIED Bender, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Biscaldi, Monica UNSPECIFIED UNSPECIFIED UNSPECIFIED Smyrnis, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-317895
DOI:	10.1038/s41598-020-73022-2
Journal or Publication Title:	Sci Rep
Volume:	10
Number:	1
Date:	2020
Publisher:	NATURE RESEARCH
Place of Publication:	BERLIN
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AUDITORY-VISUAL INTEGRATION; BILATERAL STIMULUS ARRAYS; INDEX FOCUSED ATTENTION; FUNCTIONAL CONNECTIVITY; SPECTRUM DISORDERS; SHIFTING-DEFICITS; SPEECH-PERCEPTION; HUMANS; WINDOW; MODEL Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31789