Mehler, Katrin ORCID: 0000-0002-3052-2147, Broer, Alexander, Roll, Claudia, Goepel, Wolfgang, Wieg, Christian, Jahn, Peter, Teig, Norbert, Hoehn, Thomas, Welzing, Lars, Vochem, Matthias, Hoppenz, Marc, Buehrer, Christoph, Franklin, Jeremy, Roth, Bernhard, Herting, Egbert and Kribs, Angela . Developmental outcome of extremely preterm infants is improved after less invasive surfactant application: Developmental outcome after LISA. Acta Paediatr.. HOBOKEN: WILEY. ISSN 1651-2227

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Abstract

Aim The aim of this study was to evaluate neurocognitive outcome at 24 months of corrected age after less invasive surfactant application (LISA) in preterm infants born at 23-26 weeks of gestational age. Methods Surviving participants of a LISA trial conducted in 13 German level III neonatal intensive care units were reviewed for assessment of developmental outcome, hearing and vision problems, growth and rehospitalisation days. Maternal depression, breastfeeding rates and socio-economic factors were evaluated as potentially confounding factors. Results In total, 156/182 infants took part in the study, 78 had received surfactant via LISA and 78 via endotracheal intubation. 22% of LISA infants compared to 42% of intubated infants had a psychomotor development index (PDI) <70 (0.012). A significant difference in mental development index (MDI) was observed in the stratum of more mature infants (25 and 26 weeks of GA). For this group, MDI < 70 was observed in 4% of LISA infants vs 21% of intubated infants (P = 0.008). Conclusion At 24 months of age, the LISA-treated infants scored less often PDI < 70 and had similar results in MDI. Infants born at 25 and 26 weeks treated with LISA had lower rates of severe disability. LISA is safe and may be superior.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mehler, KatrinUNSPECIFIEDorcid.org/0000-0002-3052-2147UNSPECIFIED
Broer, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roll, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goepel, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wieg, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jahn, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teig, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoehn, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Welzing, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vochem, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoppenz, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buehrer, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franklin, JeremyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roth, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herting, EgbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kribs, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-318324
DOI: 10.1111/apa.15565
Journal or Publication Title: Acta Paediatr.
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1651-2227
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ASSOCIATION; DISTRESSMultiple languages
PediatricsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31832

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