Universität zu Köln

Park, Su-Chan, Hwang, Sungmin and Krug, Joachim ORCID: 0000-0002-2143-6490 (2020). Distribution of the number of fitness maxima in Fisher's geometric model. J. Phys. A-Math. Theor., 53 (38). BRISTOL: IOP PUBLISHING LTD. ISSN 1751-8121

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Abstract

Fisher's geometric model describes biological fitness landscapes by combining a linear map from the discrete space of genotypes to ann-dimensional Euclidean phenotype space with a nonlinear, single-peaked phenotype-fitness map. Genotypes are represented by binary sequences of lengthL, and the phenotypic effects of mutations at different sites are represented byLrandom vectors drawn from an isotropic Gaussian distribution. Recent work has shown that the interplay between the genotypic and phenotypic levels gives rise to a range of different landscape topographies that can be characterised by the number of local fitness maxima. Extending our previous study of the mean number of local maxima, here we focus on the distribution of the number of maxima when the limitL -> infinity is taken at finiten. We identify the typical scale of the number of maxima for generaln, and determine the full scaled probability density and two point correlation function of maxima for the one-dimensional case. We also elaborate on the close relation of the model to the anti-ferromagnetic Hopfield model withnrandom continuous pattern vectors, and show that many of our results carry over to this setting. More generally, we expect that our analysis can help to elucidate the fluctuation structure of metastable states in various spin glass problems.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Park, Su-Chan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hwang, Sungmin UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Joachim UNSPECIFIED orcid.org/0000-0002-2143-6490 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-318335
DOI:	10.1088/1751-8121/ab9780
Journal or Publication Title:	J. Phys. A-Math. Theor.
Volume:	53
Number:	38
Date:	2020
Publisher:	IOP PUBLISHING LTD
Place of Publication:	BRISTOL
ISSN:	1751-8121
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Physics > Institut für Biologische Physik
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language METASTABLE STATES; PROTEIN EVOLUTION; SPIN-GLASS; LANDSCAPES; EPISTASIS; COMPLEXITY; SYSTEMS Multiple languages Physics, Multidisciplinary; Physics, Mathematical Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/31833