Ramani, Anand, Mueller, Lisa, Ostermann, Philipp N., Gabriel, Elke, Abida-Islam, Pranty, Mueller-Schiffmann, Andreas, Mariappan, Aruljothi, Goureau, Olivier, Gruell, Henning, Walker, Andreas, Andree, Marcel, Hauka, Sandra, Houwaart, Torsten, Dilthey, Alexander, Wohlgemuth, Kai, Omran, Heymut, Klein, Florian, Wieczorek, Dagmar, Adams, Ortwin, Timm, Joerg, Korth, Carsten, Schaal, Heiner and Gopalakrishnan, Jay (2020). SARS-CoV-2 targets neurons of 3D human brain organoids. Embo J., 39 (20). HOBOKEN: WILEY. ISSN 1460-2075

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Abstract

COVID-19 pandemic caused bySARS-CoV-2 infection is a public health emergency.COVID-19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects ofSARS-CoV-2 on the central nervous system (CNS). Here, we show that a Dusseldorf isolate ofSARS-CoV-2 enters 3D human brain organoids within 2 days of exposure. We identified thatSARS-CoV-2 preferably targets neurons of brain organoids. Imaging neurons of organoids reveal thatSARS-CoV-2 exposure is associated with altered distribution of Tau from axons to soma, hyperphosphorylation, and apparent neuronal death. Our studies, therefore, provide initial insights into the potential neurotoxic effect ofSARS-CoV-2 and emphasize that brain organoids could modelCNSpathologies ofCOVID-19.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ramani, AnandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ostermann, Philipp N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gabriel, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abida-Islam, PrantyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller-Schiffmann, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mariappan, AruljothiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goureau, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruell, HenningUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walker, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andree, MarcelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hauka, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Houwaart, TorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dilthey, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wohlgemuth, KaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Omran, HeymutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klein, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wieczorek, DagmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adams, OrtwinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timm, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Korth, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaal, HeinerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gopalakrishnan, JayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-318435
DOI: 10.15252/embj.2020106230
Journal or Publication Title: Embo J.
Volume: 39
Number: 20
Date: 2020
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1460-2075
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TAU; PHOSPHORYLATION; INFECTIONMultiple languages
Biochemistry & Molecular Biology; Cell BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31843

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