Bae-Gartz, Inga, Kasper, Philipp, Grossmann, Nora, Breuer, Saida, Janoschek, Ruth, Kretschmer, Tobias ORCID: 0000-0002-4202-0806, Appel, Sarah, Schmitz, Lisa, Vohlen, Christina, Quaas, Alexander, Schweiger, Michal R., Grimm, Christina ORCID: 0000-0002-4676-8870, Fischer, Axel, Ferrari, Nina, Graf, Christine, Frese, Christian K., Lang, Sonja, Demir, Muenevver, Schramm, Christoph, Fink, Gregor, Goeser, Tobias, Doetsch, Joerg and Hucklenbruch-Rother, Eva (2020). Maternal exercise conveys protection against NAFLD in the offspring via hepatic metabolic programming. Sci Rep, 10 (1). BERLIN: NATURE RESEARCH. ISSN 2045-2322

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Abstract

Maternal exercise (ME) during pregnancy has been shown to improve metabolic health in offspring and confers protection against the development of non-alcoholic fatty liver disease (NAFLD). However, its underlying mechanism are still poorly understood, and it remains unclear whether protective effects on hepatic metabolism are already seen in the offspring early life. This study aimed at determining the effects of ME during pregnancy on offspring body composition and development of NAFLD while focusing on proteomic-based analysis of the hepatic energy metabolism during developmental organ programming in early life. Under an obesogenic high-fat diet (HFD), male offspring of exercised C57BL/6J-mouse dams were protected from body weight gain and NAFLD in adulthood (postnatal day (P) 112). This was associated with a significant activation of hepatic AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor alpha (PPAR alpha) and PPAR coactivator-1 alpha (PGC1 alpha) signaling with reduced hepatic lipogenesis and increased hepatic beta-oxidation at organ programming peak in early life (P21). Concomitant proteomic analysis revealed a characteristic hepatic expression pattern in offspring as a result of ME with the most prominent impact on Cholesterol 7 alpha-hydroxylase (CYP7A1). Thus, ME may offer protection against offspring HFD-induced NAFLD by shaping hepatic proteomics signature and metabolism in early life. The results highlight the potential of exercise during pregnancy for preventing the early origins of NAFLD.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bae-Gartz, IngaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kasper, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grossmann, NoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Breuer, SaidaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janoschek, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kretschmer, TobiasUNSPECIFIEDorcid.org/0000-0002-4202-0806UNSPECIFIED
Appel, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmitz, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vohlen, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quaas, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schweiger, Michal R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grimm, ChristinaUNSPECIFIEDorcid.org/0000-0002-4676-8870UNSPECIFIED
Fischer, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferrari, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graf, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frese, Christian K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lang, SonjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demir, MuenevverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schramm, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, GregorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goeser, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doetsch, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hucklenbruch-Rother, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-318576
DOI: 10.1038/s41598-020-72022-6
Journal or Publication Title: Sci Rep
Volume: 10
Number: 1
Date: 2020
Publisher: NATURE RESEARCH
Place of Publication: BERLIN
ISSN: 2045-2322
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NONALCOHOLIC FATTY LIVER; ACTIVATED PROTEIN-KINASE; CARBOXYLASE INHIBITION; ACID HOMEOSTASIS; PPAR-ALPHA; DISEASE; PREVENTS; IMPROVES; PGC-1-ALPHA; STEATOSISMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31857

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